Foss Michael G, Nyckowski Timothy, Steffes William
Dermatology, Kansas City University-Graduate Medical Education Consortium/Advanced Dermatology and Cosmetic Surgery Orlando Dermatology Residency Program, Orlando, USA.
Cureus. 2021 Oct 3;13(10):e18460. doi: 10.7759/cureus.18460. eCollection 2021 Oct.
Erythroderma is a rare, potentially life-threatening presentation of psoriasis that can be triggered by medication reactions. Bupropion is indicated for major depressive disorder (Wellbutrin®, GlaxoSmithKline, Research Triangle Park, NC), smoking cessation (Zyban®, GlaxoSmithKline, Research Triangle Park, NC), and weight loss (when in formulation with naltrexone ER; Contrave®, Orixegen Therapeutics, La Jolla, CA). Bupropion can exacerbate psoriasis, however, this is an under-recognized side effect of the medication, particularly in the United States. We report a case of bupropion-induced erythrodermic psoriasis in a 62-year-old female who was prescribed the medication for depression. Due to the common comorbidities of depression, obesity, and tobacco abuse in psoriatic patients, all for which treatment with bupropion is indicated, it is important for physicians to be aware of the potential for a life-threatening medication reaction in this patient population.
红皮病型银屑病是一种罕见的、可能危及生命的银屑病表现形式，可由药物反应引发。安非他酮适用于治疗重度抑郁症（商品名：安非他酮缓释片，葛兰素史克公司，北卡罗来纳州三角研究园）、戒烟（商品名：载班，葛兰素史克公司，北卡罗来纳州三角研究园）以及减肥（与缓释纳曲酮合用时；商品名：Contrave，Orixegen Therapeutics公司，加利福尼亚州拉霍亚）。然而，安非他酮会加重银屑病病情，不过，这是该药物一种未得到充分认识的副作用，尤其是在美国。我们报告了一例62岁女性因抑郁症服用安非他酮后诱发红皮病型银屑病的病例。由于银屑病患者常伴有抑郁症、肥胖症和烟草滥用等共病，而这些疾病均有使用安非他酮进行治疗的指征，因此医生了解该患者群体中可能出现危及生命的药物反应至关重要。
