Blandino Vincent, Bommu Veera, Mbah Stephen, Rizvi Ali J
Internal Medicine, RWJBarnabas Health Community Medical Center, Toms River, USA.
Cureus. 2025 Jul 22;17(7):e88542. doi: 10.7759/cureus.88542. eCollection 2025 Jul.
Understanding unintentional and adverse reactions to medications is key in pharmacologic therapy. These adverse effects can range from mild, well-tolerated symptoms to detrimental consequences for the patient. These symptoms can also range in terms of organ system involvement, some of which may be isolated to only the skin, while others can create end-organ damage and involve multiple systems. Psoriasis, a common inflammatory skin condition, can also be found as an adverse reaction to medications, particularly bupropion, also known as Wellbutrin. We present a rare finding of biopsy-proven erythrodermic psoriasis (EP) in a 40-year-old female with no previous history of psoriasis that occurred shortly after starting bupropion. This report highlights the importance of considering drug-induced adverse reactions in patients presenting with atypical dermatologic manifestations.
了解药物的无意和不良反应是药物治疗的关键。这些不良反应的范围可以从轻微的、耐受性良好的症状到对患者有害的后果。这些症状在涉及的器官系统方面也有所不同，其中一些可能仅局限于皮肤，而另一些则可能导致终末器官损伤并累及多个系统。银屑病是一种常见的炎症性皮肤病，也可作为药物的不良反应出现，尤其是安非他酮，也称为威博隽。我们报告了一例罕见病例，一名40岁女性，既往无银屑病病史，在开始服用安非他酮后不久出现经活检证实的红皮病型银屑病（EP）。本报告强调了在出现非典型皮肤表现的患者中考虑药物性不良反应的重要性。
