Lin Binwei, Du Huan, Fan Jinjia, Huang Dan, Gao Feng, Li Jie, Zhang Yu, Feng Gang, Dai Tangzhi, Du Xiaobo
Department of Oncology, Nuclear Medicine Laboratory of Mianyang Central Hospital, Mianyang Central Hospital, Mianyang, China.
Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Front Oncol. 2021 Oct 22;11:750741. doi: 10.3389/fonc.2021.750741. eCollection 2021.
The prognosis of advanced malignant tumors is very poor, and effective treatment is limited. Radioimmunotherapy (RIT) is a novel treatment method. However, its anti-tumor effect is relatively low in solid tumors, which is mainly due to the blood-tumor barrier preventing RIT from penetrating the tumor, resulting in an insufficient dose. Low-intensity ultrasound with microbubbles (USMB) has proven capable of opening the blood-tumor barrier. The combination of the two technologies may overcome the poor anti-tumor effect of RIT and promote the clinical application of RIT in solid tumors. In this article, we reviewed the current research status of RIT in the treatment of solid tumors and the opportunities and challenges of USMB combined with RIT.
晚期恶性肿瘤的预后非常差，有效的治疗方法有限。放射免疫疗法（RIT）是一种新型治疗方法。然而，其在实体瘤中的抗肿瘤效果相对较低，这主要是由于血瘤屏障阻止RIT穿透肿瘤，导致剂量不足。微泡增强低强度超声（USMB）已被证明能够打开血瘤屏障。这两种技术的结合可能会克服RIT抗肿瘤效果不佳的问题，并促进RIT在实体瘤中的临床应用。在本文中，我们综述了RIT治疗实体瘤的当前研究现状以及USMB联合RIT的机遇与挑战。
