Dziewas Rainer, Michou Emilia, Trapl-Grundschober Michaela, Lal Avtar, Arsava Ethem Murat, Bath Philip M, Clavé Pere, Glahn Jörg, Hamdy Shaheen, Pownall Sue, Schindler Antonio, Walshe Margaret, Wirth Rainer, Wright David, Verin Eric
Department of Neurology, University Hospital Münster, Münster, Germany.
Department of Neurology and Neurorehabilitation, Klinikum Osnabrück, Osnabrück, Germany.
Eur Stroke J. 2021 Sep;6(3):LXXXIX-CXV. doi: 10.1177/23969873211039721. Epub 2021 Oct 13.
Post-stroke dysphagia (PSD) is present in more than 50% of acute stroke patients, increases the risk of complications, in particular aspiration pneumonia, malnutrition and dehydration, and is linked to poor outcome and mortality. The aim of this guideline is to assist all members of the multidisciplinary team in their management of patients with PSD. These guidelines were developed based on the European Stroke Organisation (ESO) standard operating procedure and followed the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. An interdisciplinary working group identified 20 relevant questions, performed systematic reviews and meta-analyses of the literature, assessed the quality of the available evidence and wrote evidence-based recommendations. Expert opinion was provided if not enough evidence was available to provide recommendations based on the GRADE approach. We found moderate quality of evidence to recommend dysphagia screening in all stroke patients to prevent post-stroke pneumonia and to early mortality and low quality of evidence to suggest dysphagia assessment in stroke patients having been identified at being at risk of PSD. We found low to moderate quality of evidence for a variety of treatment options to improve swallowing physiology and swallowing safety. These options include dietary interventions, behavioural swallowing treatment including acupuncture, nutritional interventions, oral health care, different pharmacological agents and different types of neurostimulation treatment. Some of the studied interventions also had an impact on other clinical endpoints such as feedings status or pneumonia. Overall, further randomized trials are needed to improve the quality of evidence for the treatment of PSD.
超过50%的急性卒中患者存在卒中后吞咽困难(PSD),这会增加并发症风险,尤其是吸入性肺炎、营养不良和脱水,并且与不良预后及死亡率相关。本指南的目的是协助多学科团队的所有成员管理PSD患者。这些指南是根据欧洲卒中组织(ESO)的标准操作程序制定的,并遵循了推荐分级、评估、制定与评价(GRADE)方法。一个跨学科工作组确定了20个相关问题,对文献进行了系统评价和荟萃分析,评估了现有证据的质量,并撰写了基于证据的推荐意见。如果没有足够的证据根据GRADE方法提供推荐意见,则提供专家意见。我们发现有中等质量的证据推荐对所有卒中患者进行吞咽困难筛查,以预防卒中后肺炎和早期死亡;而对于已被确定有PSD风险的卒中患者进行吞咽困难评估,证据质量较低。我们发现各种改善吞咽生理和吞咽安全性的治疗选择的证据质量为低到中等。这些选择包括饮食干预、行为吞咽治疗(包括针灸)、营养干预、口腔卫生保健、不同的药物制剂以及不同类型的神经刺激治疗。一些研究的干预措施也对其他临床终点有影响,如喂养状态或肺炎。总体而言,需要进一步进行随机试验以提高PSD治疗证据的质量。