Maini Kunal, Hollier Janice W, Gould Haley, Bollich Victoria, John LaForge John, Cornett Elyse M, Edinoff Amber N, Kaye Adam M, Kaye Alan D
Louisiana State University Shreveport, LA.
Louisiana State University Shreveport School of Medicine, Shreveport, LA.
Health Psychol Res. 2021 Jun 19;9(1):24932. doi: 10.52965/001c.24932. eCollection 2021.
This is a comprehensive review of the literature regarding the use of Lumateperone tosylate for schizophrenia. This review presents the background, evidence, and indications for the use of lumateperone tosylate in the treatment of schizophrenia.
Schizophrenia is a chronic mental health disorder that affects approximately 3.3 million people in the United States. Its symptoms, which must be present more than six months, are comprised of disorganized behavior and speech, a diminished capacity to comprehend reality, hearing voices unheard by others, seeing things unseen by others, delusions, decreased social commitment, and decreased motivation. The majority of these symptoms can be managed with antipsychotic medication. Lumateperone is a selective and concurrent modulator of serotonin, dopamine, and glutamate, which all mediate or modulate serious mental illness.
Schizophrenia is a complex, severe mental illness that affects how the brain processes information. There are many medications used to treat schizophrenia. One antipsychotic agent, lumateperone tosylate, is a newer agent that the FDA recently approved. The most common adverse effects are shown to be mild such as somnolence, constipation, sedation, and fatigue, with the 42 mg recommended dose. Lumateperone tosylate is an FDA-approved drug that can be given only at the 42mg dose once daily with no titration requirements.
这是一篇关于使用甲苯磺酸鲁马哌酮治疗精神分裂症的文献综述。本综述介绍了甲苯磺酸鲁马哌酮用于治疗精神分裂症的背景、证据和适应症。
精神分裂症是一种慢性心理健康障碍，在美国约影响330万人。其症状（必须持续超过六个月）包括行为和言语紊乱、理解现实能力下降、幻听、幻视、妄想、社会参与度降低和动机减弱。这些症状大多可用抗精神病药物控制。鲁马哌酮是一种血清素、多巴胺和谷氨酸的选择性及协同调节剂，这些神经递质均介导或调节严重精神疾病。
精神分裂症是一种复杂、严重的精神疾病，会影响大脑处理信息的方式。有许多药物用于治疗精神分裂症。一种抗精神病药物甲苯磺酸鲁马哌酮是美国食品药品监督管理局（FDA）最近批准的新药。在推荐剂量42毫克时，最常见的不良反应显示为轻度，如嗜睡、便秘、镇静和疲劳。甲苯磺酸鲁马哌酮是一种FDA批准的药物，仅能以42毫克的剂量每日给药一次，无需滴定。
