Lian Shi-Jun, Hu Zhong-Xin, Lan Zhong, Wen Rong-Fu, Ma Xue-Hu
Liaoning Key Laboratory of Clean Utilization of Chemical Resources, Institute of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
ACS Omega. 2021 Oct 24;6(43):28912-28922. doi: 10.1021/acsomega.1c03890. eCollection 2021 Nov 2.
In the process of industrial crystallization, it is always difficult to balance the secondary nucleation rate and metastable zone width (MSZW). Herein, we report an experimental and numerical study for the cooling crystallization of paracetamol in an oscillatory flow crystallizer (OFC), finding the optimal operating conditions for balancing the secondary nucleation rate and MSZW. The results show that the MSZW decreases with the increase of oscillation Reynolds number ( ). Compared to the traditional stirring system, the OFC has an MSZW three times larger than that of the stirring system under a similar power density of consumption. With the numerical simulation, the OFC can produce a stable space environment and instantaneous strong disturbance, which is conducive to the crystallization process. Above all, a high is favorable to produce a sufficient nucleation rate, which may inevitably constrict the MSZW to a certain degree. Then, the optimization strategy of the operating parameter ( ) in the OFC is proposed.
在工业结晶过程中，始终难以平衡二次成核速率和亚稳区宽度（MSZW）。在此，我们报告了对扑热息痛在振荡流结晶器（OFC）中冷却结晶的实验和数值研究，找到了平衡二次成核速率和MSZW的最佳操作条件。结果表明，MSZW随振荡雷诺数（ ）的增加而减小。与传统搅拌系统相比，在相似的功耗功率密度下，OFC的MSZW比搅拌系统大两倍。通过数值模拟，OFC能够产生稳定的空间环境和瞬时强扰动，这有利于结晶过程。最重要的是，高 有利于产生足够的成核速率，这可能不可避免地在一定程度上限制MSZW。然后，提出了OFC中操作参数（ ）的优化策略。
