Department of Ophthalmology, Bursa Yüksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey.
Department of Internal Medicine, Division of Rheumatology, Bursa Yüksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey.
Int Ophthalmol. 2022 Apr;42(4):1147-1159. doi: 10.1007/s10792-021-02100-9. Epub 2021 Nov 8.
There are insufficient data in the literature on how retinal capillaries are affected in primary Sjögren's syndrome (PSS). The aim of this study was to evaluate the retinal capillary density (CD) in PSS using optical coherence tomography angiography (OCTA).
In this case-control study, 26 eyes from 13 PSS patients and 39 eyes from 20 healthy controls (HCs) were included. The CD in the regions of the superior capillary plexus (SCP), deep capillary plexus (DCP) and radial peripapillary capillaries (RPC) as well as assessment parameters of the foveal avascular zone (FAZ) were examined by OCTA.
The mean CD (%) was 50.2 ± 4.2 and 50.5 ± 3.4 in the SCP (p = 0.904), 49.2 ± 7.5 and 53.9 ± 5.7 in the DCP (p = 0.006) and 50.8 ± 2.1 and 49.8 ± 2.2 in the RPC (p = 0.088) regions in patients with PSS and HCs, respectively. In patients with PSS and HCs, the mean sizes of the FAZ were 0.243 ± 0.07 mm and 0.283 ± 0.13 mm (p = 0.142), and the mean sizes of the non-flow area were 0.480 ± 0.11 mm and 0.509 ± 0.13 mm, respectively (p = 0.359). The correlation coefficients (Rho) of retinal CD in the SCP, DCP and RPC regions with disease duration were - 0.545 (p = 0.004), - 0.389 (p = 0.050) and - 0.795 (p < 0.001), respectively.
The retinal CD in PSS is lower than that in the healthy population in deep retinal capillaries, and retinal CD shows a negative correlation with disease duration in PSS.
This study was not registered to clinicaltrials.gov.
原发性干燥综合征（PSS）患者的视网膜毛细血管变化的相关文献数据十分有限。本研究旨在使用光相干断层扫描血管造影术（OCTA）评估 PSS 患者的视网膜毛细血管密度（CD）。
在这项病例对照研究中，纳入了 13 例 PSS 患者的 26 只眼和 20 名健康对照者（HCs）的 39 只眼。通过 OCTA 检查了上毛细血管丛（SCP）、深层毛细血管丛（DCP）和放射状视神经乳头毛细血管（RPC）的 CD 以及黄斑无血管区（FAZ）的评估参数。
PSS 患者和 HCs 的 SCP 区域的平均 CD（%）分别为 50.2±4.2 和 50.5±3.4（p=0.904），DCP 区域分别为 49.2±7.5 和 53.9±5.7（p=0.006），RPC 区域分别为 50.8±2.1 和 49.8±2.2（p=0.088）。PSS 患者和 HCs 的 FAZ 的平均大小分别为 0.243±0.07mm 和 0.283±0.13mm（p=0.142），无血流面积的平均大小分别为 0.480±0.11mm 和 0.509±0.13mm（p=0.359）。SCP、DCP 和 RPC 区域的视网膜 CD 与疾病持续时间的相关系数（Rho）分别为-0.545（p=0.004）、-0.389（p=0.050）和-0.795（p<0.001）。
PSS 患者的视网膜 CD 在深层视网膜毛细血管中低于健康人群，并且在 PSS 中与疾病持续时间呈负相关。
本研究未在 clinicaltrials.gov 上注册。
