Department of Hematology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Endocrinology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Int J Low Extrem Wounds. 2024 Mar;23(1):104-108. doi: 10.1177/15347346211055972. Epub 2021 Nov 6.
Diabetic foot infections (DFIs) are the most complex and challenging pathological state, characterized by high complexity of management, morbidity, and mortality. Empirical antimicrobial administration is needed before the identification of the causative organisms. Microbiological profile of the diabetic foot patients is the basis of the antibiotic choice for clinicians.
76 patients visiting the Diabetic Foot Center of our Hospital for having ulcers with Wagner 3 to 5 were retrospectively surveyed for the bacterium infected. Antimicrobial susceptibility testing (AST) was implemented and the results were interpreted on the basis of the Clinical and Laboratory Standards Institute (CLSI) guidelines.
A total of 92 isolates were obtained, of which 47 strains of gram-negative bacilli (GNB) accounted for 51.1%, 41 strains of gram-positive cocci (GPC) accounted for 44.6%, and 4 strains of fungi accounted for 4.3%. Species of and are the two predominant strains. The top 4 most frequently isolated strains were (22.8%), (9.8%), (9.8%), (5.4%). The rate of resistance to methicillin was 33.3% for . The rate of extended-spectrum β-lactamases (ESBLs) production among was 60%. 50% of were resistant to carbapenems. showed high sensitivity to commonly used antibiotics. There was one isolate of spp. resistant to most antimicrobials except tigecycline and aminoglycosides.
and are the two predominant species. The resistance to antibiotics of showed optimistic results. However, the high prevalence of CRKP imposed a challenging issue for clinical physicians.
糖尿病足感染（DFI）是最复杂和最具挑战性的病理状态，其特点是管理的复杂性高、发病率和死亡率高。在确定病原体之前，需要进行经验性抗菌药物治疗。糖尿病足患者的微生物谱是临床医生选择抗生素的基础。
回顾性调查了我院糖尿病足中心 76 例溃疡处于 Wagner 3 至 5 期的患者的细菌感染情况。进行了抗菌药物敏感性试验（AST），并根据临床和实验室标准协会（CLSI）指南解释结果。
共获得 92 株分离株，其中革兰氏阴性杆菌（GNB）47 株，占 51.1%，革兰氏阳性球菌（GPC）41 株，占 44.6%，真菌 4 株，占 4.3%。 和 是两种主要菌株。前 4 种最常分离的菌株分别为 （22.8%）、 （9.8%）、 （9.8%）、 （5.4%）。 对甲氧西林的耐药率为 33.3%。 产超广谱β-内酰胺酶（ESBLs）的比例为 60%。50%的 对碳青霉烯类耐药。 对常用抗生素表现出高度敏感性。除替加环素和氨基糖苷类外，有一株 对大多数抗生素均耐药。
和 是两种主要菌株。对抗生素的耐药性结果乐观。然而，CRKP 的高流行率给临床医生带来了挑战。
