Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Emergency, Istanbul University, Istanbul, Turkey.
Department of Pediatric Hematology-Oncology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
Biomarkers. 2022 Feb;27(1):44-49. doi: 10.1080/1354750X.2021.2003432. Epub 2021 Nov 24.
Mannose-binding lectin (MBL) is a serine protease belonging to the collectins and an important factor in the inherited immune system. We aimed to reveal the distribution of different genotypes in patients diagnosed with acute bronchiolitis and pneumonia.
A total of 147 patients who applied to Paediatric Emergency between 01.12.2019 and 31.12.2020 were included in the study. Patients were divided into two subgroups: Bronchiolitis and pneumonia.
AA genotype was found to be significantly higher in healthy controls ( = 0.039). In the pneumonia group, both AB/BB genotype was significantly higher compared to healthy controls ( = 0.001). While the AA genotype was more common in patients with acute bronchiolitis, AB/BB genotypes were more common in the pneumonia group ( = 0.001). The presence of fever, crepitation, tachypnoea, pathological x-ray finding, and high leukocyte count are significantly more common in patients with AA genotype, while more than 3 days of follow-up duration and severe clinical picture were more common in patients with AB/BB genotypes ( < 0.05, for all).
Genotypes with low MBL expression were significantly more common in patients with pneumonia and severe infection. All these results reveal the importance of MBL polymorphisms and their expression in infections.
甘露聚糖结合凝集素（MBL）是一种丝氨酸蛋白酶，属于凝集素家族，是先天免疫系统的重要因素。本研究旨在揭示不同基因型在急性细支气管炎和肺炎患者中的分布情况。
本研究共纳入了 2019 年 12 月 1 日至 2020 年 12 月 31 日期间在儿科急诊就诊的 147 名患者。将患者分为细支气管炎和肺炎两个亚组。
AA 基因型在健康对照组中显著更高（=0.039）。在肺炎组中，AB/BB 基因型与健康对照组相比显著更高（=0.001）。而在急性细支气管炎患者中，AA 基因型更为常见，而在肺炎组中 AB/BB 基因型更为常见（=0.001）。AA 基因型患者中发热、啰音、呼吸急促、X 线异常表现和白细胞计数升高的情况更为常见，而 AB/BB 基因型患者中随访时间超过 3 天和病情严重的情况更为常见（均<0.05）。
肺炎和严重感染患者中低 MBL 表达的基因型更为常见。所有这些结果都揭示了 MBL 多态性及其在感染中的表达的重要性。
