Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université de Paris, Paris, France.
Biochem Soc Trans. 2021 Dec 17;49(6):2831-2839. doi: 10.1042/BST20210810.
Mechanical forces, such as compression, shear stress and stretching, play major roles during development, tissue homeostasis and immune processes. These forces are translated into a wide panel of biological responses, ranging from changes in cell morphology, membrane transport, metabolism, energy production and gene expression. Recent studies demonstrate the role of autophagy in the integration of these physical constraints. Here we focus on the role of autophagy in the integration of shear stress induced by blood and urine flows in the circulatory system and the kidney, respectively. Many studies highlight the involvement of the primary cilium, a microtubule-based antenna present at the surface of many cell types, in the integration of extracellular stimuli. The cross-talk between the molecular machinery of autophagy and that of the primary cilium in the context of shear stress is revealed to be an important dialog in cell biology.
机械力，如压缩、切应力和拉伸，在发育、组织内稳态和免疫过程中发挥主要作用。这些力被转化为广泛的生物学反应，包括细胞形态、膜转运、代谢、能量产生和基因表达的变化。最近的研究表明自噬在整合这些物理限制中的作用。在这里，我们专注于自噬在整合分别由血液循环和尿液流动引起的剪切应力中的作用。许多研究强调了初级纤毛的作用，初级纤毛是许多细胞类型表面存在的基于微管的天线。自噬的分子机制与剪切应力背景下的初级纤毛的分子机制之间的串扰被揭示为细胞生物学中的一个重要对话。
