Evidence-Based Health Program, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), R. Botucatu, 740 - 3o andar, Vila Clementino, São Paulo, SP, CEP 04023-900, Brazil.
Biological and Health Sciences Department, Universidade Federal de Amapa (UNIFAP), Macapá, AP, Brazil.
Clin Rheumatol. 2022 Apr;41(4):1145-1152. doi: 10.1007/s10067-021-05977-0. Epub 2021 Nov 8.
Resistance training (RT) is well tolerated and has shown promise for decreasing fatigue. However, the effects of RT have never been examined in primary Sjogren's syndrome (pSS).
To assess the feasibility, effectiveness, and safety of a resistance exercise program on fatigue in patients with pSS.
This is a parallel, single-blind randomized trial. Women aged 18 years or older, diagnosed with pSS according to the American-European criteria, were included. We randomized 59 participants to a resistance training group (RT) or a control group (CG). Participants in the RT group performed a 16-week resistance exercise program. The sessions consisted of three sets of resistance exercises (10 repetitions each) at 60 to 80% of 1 repetition maximum, designed to improve whole-body strength. The participants in the CG received their usual pharmacological treatment and instructions regarding disease control, pain management, sleep hygiene, and activities of daily living. To compare intergroup and intragroup variability, a one-factor repeated-measures analysis of variance (ANOVA) was used.
RT effectively improved fatigue, pain, functional capacity, emotional aspects, vitality, and subjective perception of disease activity by the patient. No between-group differences were found in the ESSPRI mental score, ESSDAI, SF-36-Physical Aspects, SF-36-General Health, SF-36-Social aspects, and SF-36-Mental Health after the training period.
An RT program was safe and effective in improving fatigue, pain, functional capacity, emotional aspects, vitality, and subjective perception of disease activity by the patient in women with pSS. Key Points • This is the first study to evaluate the effects of a resistance training program on fatigue in patients with primary Sjogren's syndrome. • A resistance training program was shown to be effective in improving fatigue in patients with primary Sjogren's syndrome. • A resistance training program is well-tolerated, has good compliance, and is not associated with serious adverse effects in patients with primary Sjogren's syndrome.
抗阻训练（RT）耐受性良好，并且已显示出可降低疲劳的潜力。然而，RT 的效果从未在原发性干燥综合征（pSS）患者中进行过研究。
评估阻力运动方案对 pSS 患者疲劳的可行性、有效性和安全性。
这是一项平行、单盲随机试验。纳入年龄在 18 岁及以上、根据美国-欧洲标准诊断为 pSS 的女性。我们将 59 名参与者随机分为抗阻训练组（RT）或对照组（CG）。RT 组的参与者进行了 16 周的抗阻运动方案。每次训练包括三组抗阻运动（每组 10 次重复），强度为 1 次最大重复次数的 60%至 80%，旨在提高全身力量。CG 组的参与者接受了常规的药物治疗以及疾病控制、疼痛管理、睡眠卫生和日常生活活动方面的指导。为了比较组间和组内的变化，使用单因素重复测量方差分析（ANOVA）进行分析。
RT 有效地改善了疲劳、疼痛、功能能力、情绪方面、活力和患者对疾病活动的主观感知。在训练期后，ESSPRI 精神评分、ESSDAI、SF-36-生理方面、SF-36-总体健康、SF-36-社会方面和 SF-36-心理方面，RT 组和 CG 组之间无差异。
抗阻训练方案在改善 pSS 女性的疲劳、疼痛、功能能力、情绪方面、活力和患者对疾病活动的主观感知方面是安全且有效的。关键点：• 这是第一项评估抗阻训练方案对原发性干燥综合征患者疲劳影响的研究。• 抗阻训练方案在改善原发性干燥综合征患者的疲劳方面是有效的。• 抗阻训练方案在原发性干燥综合征患者中耐受性良好、依从性好，且不会引起严重不良反应。
