. 中的抗菌和细胞毒性薁环醌
Antimicrobial and Cytotoxic Angucyclic Quinones from .
机构信息
National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Thailand Science Park, Phahonyothin Road, Tambon Khlong Nueng, Amphoe Khlong Luang, Pathum Thani 12120, Thailand.
出版信息
J Nat Prod. 2021 Nov 26;84(11):2775-2785. doi: 10.1021/acs.jnatprod.1c00232. Epub 2021 Nov 8.
Eight new angucyclic quinones, miaosporones A to H (-), along with the previously described metabolites 8-hydroxy-3-methylbenz[]anthraquinone (), tetrangulol (), 5,6-dihydro-1,8-dihydroxy-3-methybenz[]anthracene-7,12-quinone (), and SF2315A (), were isolated from the terrestrial actinomycete TBRC 5172 obtained from sediment collected from the Huai Yang reservoir, Prachuap Khiri Khan Province, Thailand. The relative and absolute configurations of the new compounds were determined from analysis of NMR spectroscopic and X-ray crystallographic data. Miaosporone A exhibited antimalarial activity against K1 and antibacterial activity against with respective IC values of 2.5 and 2.4 μM and displayed cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells.
从泰国巴蜀府淮扬水库沉积物中分离得到的陆生放线菌 TBRC 5172 中，分离得到了 8 个新的角环醌类化合物，分别为 miaosporones A 至 H（-），以及之前描述的代谢产物 8-羟基-3-甲基苯并[α]蒽醌（）、四氢-1,8-二羟基-3-甲基苯并[α]蒽-7,12-醌（）和 SF2315A（）。从 NMR 光谱和 X 射线晶体学数据分析中确定了新化合物的相对和绝对构型。Miaosporone A 对 K1 表现出抗疟活性，对 表现出抗菌活性，IC 值分别为 2.5 和 2.4 μM，对癌细胞（MCF-7 和 NCI-H187）和非癌细胞（Vero）均具有细胞毒性活性。
Zotero 插件