Phatchana Ratchanee, Yenjai Chavi
Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Planta Med. 2014 Jun;80(8-9):719-22. doi: 10.1055/s-0034-1368568. Epub 2014 Jun 17.
Three new coumarins and 13 known compounds were isolated from the stem bark of Toddalia asiatica. Compounds 1, 3, 8, and 9 showed cytotoxicity against the NCI-H187 cell line with IC50 values ranging from 6 to 9 µg/mL. Compounds 4 and 9 exhibited cytotoxicity against the MCF-7 cell line with IC50 values of 3.17 and 9.79 µg/mL, respectively. Compound 9 also displayed cytotoxic activity against KB cells with an IC50 value of 8.63 µg/mL. In addition, compound 14 showed antimalarial activity against Plasmodium falciparum with an IC50 value of 3.66 µg/mL. Compounds 5, 9, and 16 exhibited antituberculosis activity against Mycobacterium tuberculosis with MIC values of 50, 50, and 25 µg/mL, respectively.
从飞龙掌血的茎皮中分离出了三种新香豆素和13种已知化合物。化合物1、3、8和9对NCI-H187细胞系表现出细胞毒性，IC50值在6至9μg/mL之间。化合物4和9对MCF-7细胞系表现出细胞毒性，IC50值分别为3.17和9.79μg/mL。化合物9对KB细胞也显示出细胞毒性活性，IC50值为8.63μg/mL。此外，化合物14对恶性疟原虫表现出抗疟活性，IC50值为3.66μg/mL。化合物5、9和16对结核分枝杆菌表现出抗结核活性，MIC值分别为50、50和25μg/mL。
