Yoshida H, Adachi H, Naniwa S, Yumoto T, Morimoto K, Furuse K
Acta Pathol Jpn. 1987 Feb;37(2):305-13. doi: 10.1111/j.1440-1827.1987.tb03066.x.
Telangiectatic osteosarcoma (TOS) which occurred in the metaphysis of the right femoral bone in a 13-year-old female was reported. It showed osteolytic and cystic lesion without sclerotic change on roentgenogram and consisted histologically of various sized blood-filled spaces lined by layers of round to oval tumor cells in the thin fibrous septa. In some solid areas, a proliferation of atypical tumor cells with large prominent nucleoli was evident, embedded in the lace-like osteoid tissue. Mitotic cells were easily encountered. A large population of tumor cells revealed high alkaline phosphatase activity as well as 5'-nucleotidase activity, indicative of osteogenic cell origin. Ultrastructurally, they showed osteogenic characteristics of well-developed rough endoplasmic reticula, cytoplasmic microfibrils, and dense bodies, but not for those of endothelial cells. In this report, we suggest that alkaline phosphatase activity in biopsy and surgical specimens is useful for distinguishing TOS from other osteolytic bone tumors, with regard to its ontogenic discussion.
报告了一名13岁女性右股骨骨干骺端发生的毛细血管扩张性骨肉瘤（TOS）。X线片显示为溶骨性囊性病变，无硬化改变，组织学上由薄纤维间隔内大小不一的充满血液的间隙组成，间隙内衬有多层圆形至椭圆形肿瘤细胞。在一些实性区域，可见具有大而突出核仁的非典型肿瘤细胞增殖，包埋于花边样类骨组织中。易见有丝分裂细胞。大量肿瘤细胞显示高碱性磷酸酶活性以及5'-核苷酸酶活性，提示成骨细胞起源。超微结构显示，它们具有发育良好的粗面内质网、细胞质微原纤维和致密小体等成骨细胞特征，而非内皮细胞特征。在本报告中，我们认为活检和手术标本中的碱性磷酸酶活性在其发生学讨论方面有助于将TOS与其他溶骨性骨肿瘤区分开来。
