Sanerkin N G
Cancer. 1980 Jul 1;46(1):178-85. doi: 10.1002/1097-0142(19800701)46:1<178::aid-cncr2820460130>3.0.co;2-c.
The current definition of osteosarcoma, based on the prescence of tumor osteoid, is unsatisfactory because it fails to identify some examples of chondroblastic, fibroblastic, and anaplastic osteosarcoma having no demonstrable tumor osteoid. The tumor cells in osteosarcoma, whether osteoblastic, chondroblastic, fibroblastic, or anaplastic, contain abundant alkaline phsophatase, whereas this enzyme is scanty or absent in condrosarcoma and fibrosarcoma. It is therefore proposed that these bone sarcomas are best defined according to the origin of the constituent tumor cells and their alkaline phosphatase content: osteosarcoma--a malignant tumor of osteoblasts (alkaline phosphatase positive); chondrosarcoma--a malignant tumor of chondroblasts (alkaline phosphatase negative); and fibrosarcoma--a malignant tumor of fibroblasts (alkaline phosphatase negative).
基于肿瘤类骨质的存在对骨肉瘤的当前定义并不令人满意，因为它未能识别出一些没有可证实的肿瘤类骨质的软骨母细胞型、纤维母细胞型和间变性骨肉瘤的例子。骨肉瘤中的肿瘤细胞，无论是成骨细胞型、软骨母细胞型、纤维母细胞型还是间变性，都含有丰富的碱性磷酸酶，而这种酶在软骨肉瘤和纤维肉瘤中含量稀少或不存在。因此，有人提出，这些骨肉瘤最好根据组成肿瘤细胞的起源及其碱性磷酸酶含量来定义：骨肉瘤——成骨细胞的恶性肿瘤（碱性磷酸酶阳性）；软骨肉瘤——软骨母细胞的恶性肿瘤（碱性磷酸酶阴性）；纤维肉瘤——纤维母细胞的恶性肿瘤（碱性磷酸酶阴性）。
