Laboratory Medicine Department, La Paz University Hospital, Madrid, Spain.
Laboratory Medicine Department, La Paz University Hospital, Madrid, Spain.
Clin Chim Acta. 2021 Dec;523:497-503. doi: 10.1016/j.cca.2021.11.001. Epub 2021 Nov 5.
Analysis of acid-base status (ABS) is requested in a wide range of clinical scenarios, including in the assessment of athletes' performance and follow up, but there is a lack of high-quality biological variation (BV) data. The aims of this study were to estimate the BV of ABS related parameters in athletes and to evaluate if variables related to exercise may influence the estimates.
Eleven samples from 30 triathletes were drawn, on a monthly basis. The samples were measured for pH, pCO, bicarbonate, base excess, TCO, Ca and lactate. A CV-ANOVA was performed to calculate within-subject (CV) estimates and a linear mixed model was applied to analyze the effect of the folowing variables on the BV; health status, sampling interval, intensity and duration of the exercise.
For all ABS parameters except for lactate, higher CV estimates were found in athletes than what have been reported for the general population. No significant effect of the exercise and sampling related variables were observed, except for Ca.
This difference founds in ABS parameters between athletes and the general population could be explained by the physiological stress during exercise. Laboratories attending this population could use these BV estimates to establish quality goals.
在广泛的临床情况下都需要分析酸碱状态（ABS），包括评估运动员的表现和随访，但缺乏高质量的生物学变异（BV）数据。本研究的目的是评估运动员 ABS 相关参数的 BV，并评估与运动相关的变量是否会影响这些估计值。
从 30 名三项全能运动员中抽取了 11 个样本，每月采集一次。对 pH、pCO、碳酸氢盐、碱剩余、TCO、Ca 和乳酸进行了测量。采用 CV-ANOVA 计算个体内（CV）估计值，并应用线性混合模型分析以下变量对 BV 的影响：健康状况、采样间隔、运动强度和持续时间。
除了乳酸之外，所有 ABS 参数的 CV 估计值在运动员中均高于一般人群的报道值。除了 Ca 之外，运动和采样相关变量对 BV 没有显著影响。
运动员和一般人群之间 ABS 参数的这种差异可能是由运动期间的生理应激引起的。为这一人群服务的实验室可以使用这些 BV 估计值来建立质量目标。
