Regional Center for Agricultural Research in Settat, National Institute for Agricultural Research (INRA), P.O. Box 589, Settat, 26000, Morocco; Hassan First University of Settat, Faculty of Sciences and Techniques, Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, P.O. Box 577, 26000, Settat, Morocco.
Hassan First University of Settat, Faculty of Sciences and Techniques, Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, P.O. Box 577, 26000, Settat, Morocco.
Toxicology. 2022 Jan 15;465:153025. doi: 10.1016/j.tox.2021.153025. Epub 2021 Nov 5.
Fluoride is a natural element widely distributed in the environment and plays an important role in the growth of humans and animals. However, in many species, high concentrations of fluoride induce several problems, such as dental, skeletal, and non-skeletal fluorosis. Sheep living in endemic areas are sensitive to the chronic toxicity of fluoride, and they have been found to suffer not only from teeth and bone problems but also from other organs. Studies indicating the chronic harmful effects of fluoride on teeth, bones, blood biochemical parameters, kidney, liver, heart, reproductive system and growth in sheep have been clearly summarized in this review. Besides, this work also includes updated progress in terms of prevention or reduction of fluoride toxicity in this species.
氟是一种广泛分布于环境中的天然元素，在人类和动物的生长发育中发挥着重要作用。然而，在许多物种中，高浓度的氟化物会引起多种问题，如氟斑牙、氟骨症和非骨氟中毒。生活在流行地区的绵羊对氟化物的慢性毒性敏感，它们不仅会出现牙齿和骨骼问题，还会出现其他器官问题。本综述清楚地总结了氟化物对绵羊牙齿、骨骼、血液生化参数、肾脏、肝脏、心脏、生殖系统和生长的慢性有害影响的研究。此外，本工作还包括了在预防或减轻该物种氟化物毒性方面的最新进展。
