Haron E, Feld R, Tuffnell P, Patterson B, Hasselback R, Matlow A
Am J Med. 1987 Jul;83(1):17-26. doi: 10.1016/0002-9343(87)90492-x.
Hepatic candidiasis has been increasingly recognized as a variant of disseminated candidiasis in immunocompromised patients. Five leukemic patients with antemortem diagnosis of hepatic candidiasis are described, and 32 additional cases reported in the literature are reviewed. Cultures of the liver and/or spleen and blood cultures usually give negative results; histopathologic demonstration of Candida organisms in tissue specimens is necessary for a definitive diagnosis. Response to conventional therapy with amphotericin B is poor, and 34.4 percent of the patients died with evidence of active fungal disease. Liposome-encapsulated amphotericin B, which has been successfully used in a limited number of patients with invasive fungal disease, may be an effective and relatively nontoxic drug.
肝念珠菌病在免疫功能低下的患者中已越来越多地被认为是播散性念珠菌病的一种变体。本文描述了5例生前诊断为肝念珠菌病的白血病患者，并对文献中另外报道的32例病例进行了回顾。肝脏和/或脾脏培养以及血培养通常结果为阴性；组织标本中念珠菌的组织病理学证实对于明确诊断是必要的。两性霉素B常规治疗效果不佳，34.4%的患者死于活动性真菌病。脂质体包裹的两性霉素B已成功用于少数侵袭性真菌病患者，可能是一种有效且相对无毒的药物。
