University of Texas at Austin, UTEX Culture Collection of Algae, Department of Molecular Biosciences, 205 W. 24th Street (F0402), Austin, TX, 78712-1240, United States.
Curr Opin Biotechnol. 2022 Apr;74:1-7. doi: 10.1016/j.copbio.2021.10.018. Epub 2021 Nov 6.
Microalgae, including cyanobacteria, are a genetically diverse and biochemically diverse group of mostly photosynthetic organisms that can be found in nearly every ecosystem. They produce a broad range of compounds, including structural and bioactive lipids with various roles in the metabolism of the cell and potential applications in biotechnology. The majority of lipids are synthesized in the chloroplast using acetate to produce fatty acids and terpenoids via the acetate pathway and methylerythritol phosphate deoxy-xylulose phosphate pathway, respectively. This review will highlight the major groups of microalgal lipids as well as their applications in food, fuels, and specialty chemicals. Future directions include the development of microalgal chassis organisms and molecular tools to manipulate lipid synthesis for the enhanced production of target metabolites.
微藻,包括蓝藻,是一组遗传和生化多样性的光合生物体,几乎可以在每种生态系统中找到。它们产生多种化合物,包括结构和生物活性脂质,在细胞代谢中具有各种作用,并且在生物技术中有潜在的应用。大多数脂质是在叶绿体中利用乙酸盐通过乙酸盐途径和甲基赤藓醇磷酸赤藓糖磷酸途径合成脂肪酸和萜类化合物的。本文综述了微藻脂质的主要类别及其在食品、燃料和特种化学品中的应用。未来的方向包括开发微藻底盘生物和分子工具来操纵脂质合成,以增强目标代谢物的生产。