婴儿使用西罗莫司后出现严重高甘油三酯血症。
Severe hypertriglyceridemia following sirolimus use in an infant.
机构信息
Indiana University School of Medicine, Indianapolis, Indiana, USA.
Departments of Pediatrics and Dermatology, Indiana University, Indianapolis, Indiana, USA.
出版信息
Pediatr Dermatol. 2021 Nov;38(6):1581-1582. doi: 10.1111/pde.14853. Epub 2021 Nov 8.
PMID:34749436
Abstract
Inhibitors of mammalian target of rapamycin function to downregulate cell growth and proliferation and have off-label use in pediatrics for vascular malformations. Hypertriglyceridemia is a known side effect of mammalian target of rapamycin (mTOR) inhibitors. Further studies to better understand the incidence and treatment of hypertriglyceridemia in infants and neonates are warranted.
摘要
雷帕霉素哺乳动物靶蛋白抑制剂的作用是下调细胞生长和增殖，并且在儿科中被超适应证用于血管畸形。高甘油三酯血症是雷帕霉素哺乳动物靶蛋白（mTOR）抑制剂的已知副作用。进一步的研究对于更好地了解婴儿和新生儿高甘油三酯血症的发病率和治疗方法是必要的。
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