在刺激性接触性皮炎中的新关键参与者：居住在皮肤细胞和中性粒细胞推动炎症。
New Key Players in Irritant Contact Dermatitis: Residential Skin Cells and Neutrophils Drive Inflammation.
机构信息
Department of Dermatology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
出版信息
J Invest Dermatol. 2022 Mar;142(3 Pt A):509-512. doi: 10.1016/j.jid.2021.09.002. Epub 2021 Nov 5.
The chemokine CCL2 is a potential biomarker for progression of inflammatory skin disease. In a new article of the Journal of Investigative Dermatology, Shibuya et al. (2021) use murine experimental models to show that CCL2‒CCR2‒dependent IL-1β secretion by local skin cells and skin-infiltrating neutrophils are key drivers of skin irritation.
趋化因子 CCL2 是炎症性皮肤疾病进展的潜在生物标志物。在《皮肤病学研究杂志》的一篇新文章中，Shibuya 等人（2021 年）利用小鼠实验模型表明，局部皮肤细胞和浸润皮肤的中性粒细胞中 CCL2-CCR2 依赖性的 IL-1β 分泌是皮肤刺激的关键驱动因素。
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