老年重症肌无力患者的合并症-早发与晚发疾病的比较。
Comorbidities in older patients with myasthenia gravis - Comparison between early- and late-onset disease.
机构信息
Department of Neurology, Jagiellonian University Medical College, Krakow, Poland.
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford University Hospitals, Oxford, UK.
出版信息
Acta Neurol Scand. 2022 Mar;145(3):371-374. doi: 10.1111/ane.13549. Epub 2021 Nov 8.
BACKGROUND
Multimorbidity is an emerging challenge in older myasthenia gravis patients, which can have even greater impact on quality of life and outcome than symptoms of myasthenia.
AIMS OF THE STUDY
We aimed to investigate comorbidities in older population and compare early-onset (EOMG) and late-onset (LOMG) myasthenia patients.
METHODS
We investigated clinical information of patients from Oxford Myasthenia Centre age 50 or older. Data on 60 chronic disorders were extracted.
RESULTS
We included 327 myasthenia patients (30.9% EOMG and 69.1% LOMG) with a median age of 70 years. Comorbidities were present in 94.5% of patients and accumulated with age. Hypertension (58.4% vs. 31.7%), hypercholesterolemia (41.2% vs. 23.8%), diabetes (24.8% vs. 11.9%), cataract (15.5% vs. 5.0%) and prostate disorders (15.0% vs. 2.0%) were more common in LOMG than EOMG, but there were no differences between 70 EOMG and 70 LOMG patients matched according to age and sex.
CONCLUSIONS
Comorbidities in older patients with myasthenia are very common, increase with age, and do not differ between early- and late-onset disease.
背景
多种合并症是老年重症肌无力患者面临的一个新挑战，其对生活质量和预后的影响可能比重症肌无力的症状更为严重。
目的
本研究旨在调查老年人群中的合并症，并比较早发性（EOMG）和迟发性（LOMG）重症肌无力患者。
方法
我们调查了牛津重症肌无力中心年龄在 50 岁及以上的患者的临床信息。提取了 60 种慢性疾病的数据。
结果
我们纳入了 327 名重症肌无力患者（30.9%为 EOMG，69.1%为 LOMG），中位年龄为 70 岁。94.5%的患者存在合并症，且随着年龄的增长而增加。高血压（58.4%比 31.7%）、高胆固醇血症（41.2%比 23.8%）、糖尿病（24.8%比 11.9%）、白内障（15.5%比 5.0%）和前列腺疾病（15.0%比 2.0%）在 LOMG 中更为常见，但根据年龄和性别匹配的 70 名 EOMG 和 70 名 LOMG 患者之间没有差异。
结论
重症肌无力老年患者的合并症非常常见，随年龄增长而增加，且早发性和迟发性疾病之间没有差异。
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