McKenney J M, Wright J T, Goodman R P, Cooper L, Yunker N, Lambert C
Drug Intell Clin Pharm. 1987 Jun;21(6):517-21. doi: 10.1177/106002808702100608.
The nonsteroidal antiinflammatory drug (NSAID) indomethacin has been shown to increase blood pressure in normotensive individuals. The effect of other NSAID on blood pressure has not been as well studied. We evaluated the effects of ibuprofen, an NSAID currently available without a prescription, on 24-hour ambulatory blood pressure in ten young, healthy, normotensive women. Using a randomized, crossover, double-blind design, subjects received ibuprofen 800 mg and a placebo identical in appearance to ibuprofen three times a day for eight days with a washout period between regimens. Subjects were instructed to follow a no-added salt diet during the study. Twenty-four-hour blood pressure monitoring and 24-hour urine collection for prostaglandin E2, creatinine, and sodium were performed on days 1 and 8 of each study week. Tablet counts and a 40 percent reduction in urinary prostaglandin E2 documented compliance with ibuprofen. Ibuprofen had no significant effect on systolic or diastolic blood pressure at any hour during the 24-hour period. Mean blood pressure for the 24-hour period was 112/73 and 111/73 mm Hg on day 1 and 111/73 and 112/73 mm Hg on day 8 for placebo and ibuprofen, respectively. We conclude that ibuprofen at doses as high as 2400 mg/d for up to seven days has no effect on blood pressure in normotensive women. Further studies are needed in hypertensive subjects.
非甾体抗炎药（NSAID）吲哚美辛已被证明可使血压正常的个体血压升高。其他非甾体抗炎药对血压的影响尚未得到充分研究。我们评估了布洛芬（一种目前无需处方即可获得的非甾体抗炎药）对10名年轻、健康、血压正常女性24小时动态血压的影响。采用随机、交叉、双盲设计，受试者每天3次服用800毫克布洛芬和外观与布洛芬相同的安慰剂，共8天，各疗程之间有洗脱期。研究期间，受试者被要求遵循无盐饮食。在每个研究周的第1天和第8天进行24小时血压监测，并收集24小时尿液以检测前列腺素E2、肌酐和钠。片剂计数以及尿前列腺素E2降低40%证明受试者遵守了布洛芬服用规定。布洛芬在24小时期间的任何时刻对收缩压或舒张压均无显著影响。安慰剂组和布洛芬组在第1天24小时平均血压分别为112/73和111/73毫米汞柱，在第8天分别为111/73和112/73毫米汞柱。我们得出结论，高达2400毫克/天的布洛芬服用7天对血压正常的女性血压无影响。高血压患者需要进一步研究。
