Department of Pediatrics,Tai'an City Central Hospital, Tai'an, Shandong 271000, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2021 Nov 15;23(11):1169-1173. doi: 10.7499/j.issn.1008-8830.2107109.
A boy, aged 17 years, was admitted again due to abdominal pain, diarrhea, and eosinophilia for 3 years, which worsened for 3 days. Three years ago, the boy suffered from abdominal pain and diarrhea after eating yogurt; color Doppler ultrasound showed a large amount of peritoneal effusion, and routine blood test, bone marrow cell morphology, and ascites histological examination showed a large number of eosinophils. Three days ago, he was admitted again due to abdominal pain and diarrhea. The gastrointestinal endoscopy showed eosinophil infiltration in the angle of stomach. The boy was diagnosed with eosinophilic gastrointestinal disease (eosinophilic gastroenteritis). He was improved after the treatment with glucocorticoids and dietary avoidance, and no recurrence was observed during the one-year follow-up. It is concluded that for children who attend the hospital due to gastrointestinal symptoms such as abdominal pain and diarrhea, if there is an increase in peripheral blood eosinophils, it is necessary to consider the possibility of eosinophilic gastrointestinal disease, and eosinophil infiltration and abnormal eosinophil count in gastrointestinal tissue based on endoscopic biopsy may be the key to diagnosis.
一位 17 岁男孩因腹痛、腹泻和嗜酸性粒细胞增多 3 年，且近 3 天加重再次入院。3 年前，该男孩在食用酸奶后出现腹痛、腹泻；彩色多普勒超声显示大量腹腔积液，常规血常规、骨髓细胞形态学和腹水组织学检查显示大量嗜酸性粒细胞。3 天前，他因腹痛、腹泻再次入院。胃肠镜检查显示胃角嗜酸性粒细胞浸润。该男孩被诊断为嗜酸性粒细胞性胃肠道疾病（嗜酸性胃肠炎）。经糖皮质激素和饮食回避治疗后症状改善，随访 1 年未见复发。结论：对于因腹痛、腹泻等胃肠道症状就诊的儿童，如果外周血嗜酸性粒细胞增多，需考虑嗜酸性粒细胞性胃肠道疾病的可能，基于内镜活检的胃肠道组织嗜酸性粒细胞浸润和异常嗜酸性粒细胞计数可能是诊断的关键。
