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[聚焦2021年Rotablator高速旋磨术及来自法国PCI注册研究的数据]

[Focus on high speed rotational atherectomy by Rotablator in 2021 and datas from France PCI registry].

作者信息

Seret Dr Gabriel, Perier Dr Matthieu, Corcos Dr Thierry, Angoulvant Pr Denis, Decomis Dr Marie Pascale, Marcollet Dr Pierre, Combaret Dr Nicolas, Chassaing Dr Stephan, Thuaire Dr Christophe, Godin Dr Matthieu, Fichaux Dr Olivier, Beygui Pr Farzin, Viallard Dr Louis, Gafsi Dr Sofiène Daniel, Lesault Dr P-F, Durand Pr Éric, Boiffard Dr Emmanuel, Motreff Pr Pascal, Rangé Dr Grégoire, Benamer Dr Hakim

机构信息

Service de cardiologie, Hôpital Foch, 40 rue Worth, 92150 Suresnes, France.

Service de cardiologie, Hôpital Foch, 40 rue Worth, 92150 Suresnes, France.

出版信息

Ann Cardiol Angeiol (Paris). 2021 Dec;70(6):435-445. doi: 10.1016/j.ancard.2021.10.002. Epub 2021 Nov 7.

DOI:10.1016/j.ancard.2021.10.002
PMID:34753597
Abstract

Developed in the late 1980s, rotational atherectomy has raised a lot of hope for its innovative principle of selective ablation, allowing volume reduction (instead of redistribution) of atherosclerotic plaque, while sparing healthy tissue. Long shunned for its disappointing results on restenosis, the Rotablator finally reasserted itself in the 2000s; era of drug eluting stents and coronary angioplasty boom, thus generating emergence of complex lesions. Indeed, the Rotablator has demonstrated an undeniable benefit in complex (type C) and calcified lesions preparation (before stenting), with a procedural success rate of 95%. Although these lesions only represent a small amount (2-3%) of percutaneous coronary interventions (PCI), they remain a technical impasse for plain-old balloon angioplasty strategy, making the Rotablator more suitable for these resistant lesions' treatment. Registry data attest the safety of this therapy, with a rate of peri-procedural complications and in-hospital mortality comparable to conventional angioplasty (France PCI register). However, certain specific, rare but serious complications (burr entrapment, broken Rotawire, coronary perforation) justify trained teams, perfect knowledge of the equipment, and strict compliance with good practice guidelines. In 2018, the rise of a new method of atherectomy by intra-vascular lithotripsy (Shockwave) has coincided with Rotablator decreasing activity (this finding being biased by a general decrease in PCI activity due to Covid pandemic). This therapeutic range's enhancement revolutionizes calcified lesions treatment, tending towards precise targeting of each indication, depending in particular on calcium distribution's anatomy in the plaque.

摘要

旋磨术于20世纪80年代末研发,其选择性消融的创新原理带来了诸多希望,可减少动脉粥样硬化斑块的体积(而非重新分布),同时保留健康组织。旋磨术曾因在再狭窄方面令人失望的结果而长期被冷落,最终在21世纪重新崭露头角;当时正值药物洗脱支架时代和冠状动脉血管成形术蓬勃发展,复杂病变也随之出现。事实上,旋磨术已在复杂(C型)和钙化病变预处理(支架置入前)中显示出不可否认的益处,手术成功率达95%。尽管这些病变在经皮冠状动脉介入治疗(PCI)中仅占一小部分(2 - 3%),但它们仍是普通球囊血管成形术策略的技术难题,这使得旋磨术更适合治疗这些顽固病变。登记数据证明了该疗法的安全性,围手术期并发症发生率和院内死亡率与传统血管成形术相当(法国PCI登记处)。然而,某些特定的、罕见但严重的并发症(磨头卡滞、旋磨导丝断裂、冠状动脉穿孔)需要有训练有素的团队、对设备的充分了解以及严格遵守良好操作规范。2018年,血管内冲击波碎石术这种新的旋磨方法兴起,与此同时旋磨术的应用减少(这一发现因新冠疫情导致PCI活动普遍减少而存在偏差)。这一治疗领域的进步彻底改变了钙化病变的治疗方式,尤其根据斑块中钙分布的解剖结构,趋向于精准针对每种适应症。

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