Vidal Santiago, Bouzaher Yanis Hichem, El Motiam Ahmed, Seoane Rocío, Rivas Carmen
Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Instituto de Investigaciones Sanitarias (IDIS), 15706 Santiago de Compostela, Spain.
Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Instituto de Investigaciones Sanitarias (IDIS), 15706 Santiago de Compostela, Spain; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health Systems, Department of Ophthalmology and Vision Science, and Department of Lab Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1X5, Canada.
Semin Cell Dev Biol. 2022 Dec;132:51-61. doi: 10.1016/j.semcdb.2021.10.012. Epub 2021 Nov 6.
The phosphatidylinositol-3-kinase (PI3K)/AKT pathway is a major regulator of metabolism, migration, survival, proliferation, and antiviral immunity. Both an overactivation and an inhibition of the PI3K/AKT pathway are related to different pathologies. Activation of this signaling pathway is tightly controlled through a multistep process and its deregulation can be associated with aberrant post-translational modifications including SUMOylation. Here, we review the complex modulation of the PI3K/AKT pathway by SUMOylation and we discuss its putative incvolvement in human disease.
磷脂酰肌醇-3-激酶（PI3K）/AKT信号通路是代谢、迁移、存活、增殖和抗病毒免疫的主要调节因子。PI3K/AKT信号通路的过度激活和抑制均与不同的病理状态相关。该信号通路的激活通过一个多步骤过程受到严格控制，其失调可能与包括SUMO化在内的异常翻译后修饰有关。在此，我们综述了SUMO化对PI3K/AKT信号通路的复杂调节作用，并讨论了其在人类疾病中的潜在作用。
