Saraswat Istuti, Goel Anjana
Department of Biotechnology, GLA University, 17 km Stone, NH-2 Mathura-Delhi Road Mathura, Chaumuhan, Uttar Pradesh, India.
Curr Pharm Des. 2025;31(2):128-139. doi: 10.2174/0113816128348771240925100639.
Inflammation is a universal response of mammalian tissue to harm, comprising reactions to injuries, pathogens, and foreign particles. Liver inflammation is commonly associated with hepatocyte necrosis and apoptosis. These forms of liver cell injury initiate a sequence of events independent of the etiological basis for the inflammation and can result in hepatic disorders. It is also common for liver cancer. This review fundamentally focuses on the molecular pathways involved in hepatic inflammation. This review aims to explore the molecular pathways involved in hepatic inflammation, focusing on arachidonic acid, NF-κB, MAPK, PI3K/Akt, and JAK/STAT pathways. It investigates active compounds in herbal plants and their pharmacological characteristics. The review proposes a unique therapeutic blueprint for managing hepatic inflammation and diseases by modifying these pathways with herbal remedies.
炎症是哺乳动物组织对损伤的一种普遍反应，包括对损伤、病原体和外来颗粒的反应。肝脏炎症通常与肝细胞坏死和凋亡有关。这些形式的肝细胞损伤引发了一系列与炎症病因基础无关的事件，并可能导致肝脏疾病。这在肝癌中也很常见。本综述主要关注肝脏炎症所涉及的分子途径。本综述旨在探索肝脏炎症所涉及的分子途径，重点关注花生四烯酸、核因子-κB、丝裂原活化蛋白激酶、磷脂酰肌醇-3激酶/蛋白激酶B和Janus激酶/信号转导和转录激活因子途径。它研究了草药植物中的活性化合物及其药理特性。该综述提出了一种独特的治疗方案，通过用草药疗法调节这些途径来管理肝脏炎症和疾病。
