Habib N A, Hershman M J, Papp L, Swift I, Williamson R C, Wood C B
Int J Colorectal Dis. 1986 Jul;1(3):186-7. doi: 10.1007/BF01648448.
A radioimmunoassay was used for the detection of the human carcinoma-associated antigen CA-50 in the serum of 50 normal subjects, 16 patients with inflammatory bowel diseases and 77 patients with primary and secondary colorectal carcinomas. Serum levels in all normal patients and those with benign disease were below 17 U/ml, while 40 of 77 (51%) patients with carcinoma had levels above 17 U/ml. The sensitivity of this test was 22% for Dukes' A carcinoma, 29% for Dukes' B, 59% for Dukes' C and 73% for metastatic disease. The CA-50 levels were elevated in 7 of 9 (78%) patients who developed tumour recurrence following curative surgery compared with 15 of 43 (35%) patients who are alive and tumour free (p less than 0.05). Therefore, this test may prove useful in the diagnosis and prognosis of patients with colorectal carcinomas.
采用放射免疫分析法检测了50名正常受试者、16名炎症性肠病患者和77名原发性及继发性结直肠癌患者血清中的人癌相关抗原CA - 50。所有正常患者和良性疾病患者的血清水平均低于17 U/ml，而77名癌症患者中有40名（51%）的水平高于17 U/ml。该检测对Dukes' A期癌的敏感性为22%，对Dukes' B期为29%，对Dukes' C期为59%，对转移性疾病为73%。与43名存活且无肿瘤的患者中的15名（35%）相比，9名（78%）根治性手术后出现肿瘤复发的患者中有7名CA - 50水平升高（p < 0.05）。因此，该检测可能对结直肠癌患者的诊断和预后有帮助。
