结直肠疾病患者血清中CA 19-9与癌胚抗原（CEA）水平的比较。
Comparison of CA 19-9 and carcinoembryonic antigen (CEA) levels in the serum of patients with colorectal diseases.
作者信息
Kuusela P, Jalanko H, Roberts P, Sipponen P, Mecklin J P, Pitkänen R, Mäkelä O
出版信息
Br J Cancer. 1984 Feb;49(2):135-9. doi: 10.1038/bjc.1984.25.
Abstract
The serum levels of CA 19-9 and carcinoembryonic antigen (CEA) were determined in 37 patients with benign colorectal diseases and in 111 patients with newly discovered colorectal carcinomas or clinically verified relapses. In cancer patients, the CA 19-9 level ranged from normal (0-37 U ml-1) to 77,500 U ml-1 whereas all samples but one from patients with benign colorectal diseases had a normal value. CA 19-9 was increased in 46% and 45% of patients with an advanced (Dukes C or D) carcinoma or a verified recidive, respectively. Only one out of 26 patients (4%) with a localized (Dukes A or B) carcinoma displayed an elevated CA 19-9 level (greater than 37 U ml-1). No clear correlation was found between the CA 19-9 and CEA levels. The sensitivity of the CA 19-9 test (36%) was poorer than that of the CEA assay (69%), but the new test was markedly more specific (97% vs 70%) than the CEA assay.
摘要
对37例良性结直肠疾病患者和111例新发现的结直肠癌患者或经临床证实复发的患者测定了血清CA 19-9和癌胚抗原（CEA）水平。在癌症患者中，CA 19-9水平范围从正常（0 - 37 U/ml）到77,500 U/ml，而除1例样本外，所有良性结直肠疾病患者的样本值均正常。分别有46%和45%的晚期（杜克C或D期）癌或经证实复发的患者CA 19-9升高。在26例局限性（杜克A或B期）癌患者中，仅1例（4%）的CA 19-9水平升高（大于37 U/ml）。未发现CA 19-9和CEA水平之间存在明显相关性。CA 19-9检测的敏感性（36%）低于CEA检测（69%），但新检测的特异性（97%对70%）明显高于CEA检测。
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本文引用的文献
1
Monoclonal antibody detection of a circulating tumor-associated antigen. II. A longitudinal evaluation of patients with colorectal cancer.循环肿瘤相关抗原的单克隆抗体检测。II. 结直肠癌患者的纵向评估。
J Clin Immunol. 1982 Apr;2(2):141-9. doi: 10.1007/BF00916898.
2
Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA 19-9.针对单克隆抗体定义的肿瘤标志物CA 19-9的放射免疫分析。
Clin Chem. 1983 Mar;29(3):549-52.
3
Gastrointestinal cancer-associated antigen in immunoperoxidase assay.免疫过氧化物酶测定中的胃肠道癌相关抗原
Cancer Res. 1982 Nov;42(11):4820-3.
4
Specific antigen in serum of patients with colon carcinoma.结肠癌患者血清中的特异性抗原。
Science. 1981 Apr 3;212(4490):53-5. doi: 10.1126/science.6163212.
5
The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system.人消化系统循环癌胚抗原的放射免疫测定
Proc Natl Acad Sci U S A. 1969 Sep;64(1):161-7. doi: 10.1073/pnas.64.1.161.
6
Radioimmunoassay of carcinoembryonic antigen in extracts of human colon and stomach.人结肠和胃提取物中癌胚抗原的放射免疫测定
Int J Cancer. 1972 May 15;9(3):641-7. doi: 10.1002/ijc.2910090322.
7
Immunologic diagnosis and prognosis of human digestive-tract cancer: carcinoembryonic antigens.人类消化道癌症的免疫诊断与预后：癌胚抗原
N Engl J Med. 1972 Jan 13;286(2):83-6. doi: 10.1056/NEJM197201132860207.
8
A reappraisal of the value of carcinoembryonic antigen in the management of patients with various neoplasms.癌胚抗原在各类肿瘤患者管理中的价值再评估。
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9
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10
Isolation and characterization of carcinoembryonic antigen (CEA) extracted from normal human colon mucosa.
Immunochemistry. 1977 Feb;14(2):119-27. doi: 10.1016/0019-2791(77)90290-7.
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