Crea Antonio, Grimod Gianluca, Scalia Gianluca, Verlotta Mariarosaria, Mazzeo Lucio, Rossi Giorgio, Mattavelli Davide, Rampinelli Vittorio, Luzzi Sabino, Spena Giannantonio
Department of Neuroscience, Neurosurgery Unit, Alessandro Manzoni Hospital, Lecco, Italy.
Department of Neurosurgery, Highly Specialized Hospital of National Importance "Garibaldi", Catania, Italy.
Surg Neurol Int. 2021 Sep 30;12:485. doi: 10.25259/SNI_386_2021. eCollection 2021.
Primary intradiploic meningiomas, extra-axial tumors arising primarily in the skull, are rare. The authors reported a complex case of intradiploic intraosseous metaplastic meningioma of the left medial wall and orbital roof with the left frontal sinus invasion and left ethmoidal body bone substitution. The authors also conducted a systematic review concerning diagnosis and management of patients affected by purely calvarial intradiploic meningiomas along with a focus on fronto-orbito-ethmoidal ones.
A literature search was conducted using PubMed and Scopus databases according to preferred reporting items for systematic reviews and meta-analysis statement and with the following Mesh terms: Intradiploic, intraosseous, calvarial, and meningioma. Eligibility criteria were limited by the nature of existing literature on intradiploic meningiomas, consisting of only case series, and case reports.
A total of 128 published studies were identified through our search. 41 studies were included in this systematic review, 59 patients with a female/male ratio of 1.2/1. The mean age of the patients is of 47.69 years (range 3-84 years). Only seven out of 59 patients (11.9%) presented a complex intradiploic meningioma located in fronto-orbito-ethmoidal region like our case. In almost all patients, a gross-total resection was performed (96.6%) and only in two patients (3.4%) a subtotal resection was achieved.
The authors shared this successfully treated case to add to the overall clinical experience in the management of this rare subtype tumor, with the hope that more studies are conducted to further address the mechanism of intradiploic meningiomas development.
原发性板障内脑膜瘤是一种主要起源于颅骨的轴外肿瘤，较为罕见。作者报告了一例复杂的左侧内侧壁和眶顶板障内骨化生脑膜瘤病例，该肿瘤侵犯左侧额窦并取代左侧筛窦骨质。作者还对单纯颅骨板障内脑膜瘤患者的诊断和治疗进行了系统综述，重点关注额眶筛部脑膜瘤。
根据系统评价和Meta分析的首选报告项目声明，使用PubMed和Scopus数据库进行文献检索，检索词如下：板障内、骨内、颅骨、脑膜瘤。由于关于板障内脑膜瘤的现有文献仅包括病例系列和病例报告，纳入标准受到限制。
通过检索共识别出128篇已发表的研究。本系统综述纳入了41项研究，59例患者，女性/男性比例为1.2/1。患者的平均年龄为47.69岁（范围3 - 84岁）。59例患者中只有7例（11.9%）表现为位于额眶筛区域的复杂板障内脑膜瘤，与我们的病例相似。几乎所有患者都进行了全切除（96.6%），只有2例患者（3.4%）进行了次全切除。
作者分享了这例成功治疗的病例，以增加这种罕见亚型肿瘤治疗的整体临床经验，希望开展更多研究以进一步探讨板障内脑膜瘤的发生机制。
