Ueno Masahiro, Shimato Shinji
Department of Neurosurgery, Handa City Hospital, Handa, Aichi, Japan.
Department of Neurosurgery, Kariya Toyota General Hospital, Kariya, Aichi, Japan.
NMC Case Rep J. 2024 Jan 31;11:19-25. doi: 10.2176/jns-nmc.2023-0171. eCollection 2024.
Meningiomas originating within the bones of the skull are rare and have been reported as primary intraosseous meningiomas (PIOM). Moreover, PIOMs with a skull base location or malignant pathology are predisposed to recurrence; however, recurrence is quite rare among PIOMs characterized by a convexity location and benign pathology. Here, we present a case of extensive recurrence of a convex intraosseous meningioma with benign pathology. A 72-year-old woman presented with a headache to our hospital. Gd contrast-enhanced magnetic resonance imaging revealed an enhanced tumor in the left frontal to the parietal region extending through the calvarial bone and invading the subdural space and subcutaneous tissue. Skull radiograph and computed tomography identified a remarkable osteolytic change in the lesion. Macroscopic complete resection (MCR) of the tumor and the surrounding tissues was performed. The tumor was histopathologically diagnosed as a transitional meningioma (World Health Organization grade 1). Seven years after the surgery, the patient presented with dysarthria, and the recurrence of the tumor was identified as massive lesions extending through the calvarial bone to the orbital bone, partially protruding into the brain and scalp. MCR was performed again, with the reconstruction of the skull for an extensive calvarial area using a titanium plate. This case is unique due to the extensiveness of the recurrent tumor and its rarity. Here, we report the details of the clinical course and discuss the characteristics of this case.
起源于颅骨内的脑膜瘤较为罕见,已被报道为原发性骨内脑膜瘤(PIOM)。此外,位于颅底或具有恶性病理特征的PIOM易复发;然而,以凸面位置和良性病理为特征的PIOM复发情况相当罕见。在此,我们报告一例具有良性病理特征的凸面骨内脑膜瘤广泛复发的病例。一名72岁女性因头痛就诊于我院。钆对比增强磁共振成像显示左额叶至顶叶区域有一个强化肿瘤,延伸穿过颅骨并侵犯硬膜下间隙和皮下组织。颅骨X线片和计算机断层扫描显示病变处有明显的骨质溶解改变。对肿瘤及周围组织进行了肉眼下完全切除(MCR)。肿瘤经组织病理学诊断为过渡型脑膜瘤(世界卫生组织1级)。手术后七年,患者出现构音障碍,肿瘤复发表现为大量病变,延伸穿过颅骨至眶骨,部分突入脑内和头皮。再次进行了MCR,并使用钛板对大面积颅骨区域进行了颅骨重建。该病例因其复发性肿瘤的广泛性及其罕见性而独具特色。在此,我们报告临床病程细节并讨论该病例的特点。