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一名无症状新冠病毒感染患者偶然发现双侧急性肺栓塞

Incidental Finding of Bilateral Acute Pulmonary Emboli in a Patient With Asymptomatic COVID-19 Infection.

作者信息

Aung Htun M, Thida Aye M, Fils-Aime Melissa, Thwin Malar

机构信息

Department of Medicine, Interfaith Medical Center, Brooklyn, USA.

Department of Medicine, Woodhull Medical and Mental Health Center, Brooklyn, USA.

出版信息

Cureus. 2021 Oct 5;13(10):e18496. doi: 10.7759/cureus.18496. eCollection 2021 Oct.

DOI:10.7759/cureus.18496
PMID:34754657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8569651/
Abstract

A 58-year-old male with a history of hypertension, dyslipidemia, osteoarthritis of both knees, and morbid obesity presented to the emergency department for opioid detoxification. He complained of generalized soreness, anxiety, and difficulty sleeping but denied signs and symptoms suggestive of coronavirus disease 2019 (COVID-19) infection. His COVID-19 polymerase chain reaction (PCR) result came back positive, and his D-dimer level was 5373 ng/mL. A computed tomography pulmonary angiogram showed a moderate burden of bilateral acute pulmonary emboli. He was managed with enoxaparin sodium subcutaneous therapeutic dose for three days, followed by oral apixaban 10 mg twice a day for seven days and then 5 mg twice a day for six months. To date, the rate of venous thromboembolism (VTE) in nonhospitalized patients with COVID-19 has not been reported, and current guidelines do not recommend thromboprophylaxis for these patients.

摘要

一名58岁男性,有高血压、血脂异常、双膝骨关节炎和病态肥胖病史,因阿片类药物脱毒入住急诊科。他主诉全身酸痛、焦虑和睡眠困难,但否认有提示2019冠状病毒病(COVID-19)感染的体征和症状。他的COVID-19聚合酶链反应(PCR)结果呈阳性,D-二聚体水平为5373 ng/mL。计算机断层扫描肺血管造影显示双侧急性肺栓塞负担中等。他接受了三天皮下治疗剂量的依诺肝素钠治疗,随后口服阿哌沙班,先10 mg每日两次,共七天,然后5 mg每日两次,持续六个月。迄今为止,尚未报告非住院COVID-19患者的静脉血栓栓塞(VTE)发生率,目前的指南也不建议对这些患者进行血栓预防。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d71/8569651/1b48a10457e5/cureus-0013-00000018496-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d71/8569651/1b48a10457e5/cureus-0013-00000018496-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d71/8569651/1b48a10457e5/cureus-0013-00000018496-i01.jpg

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本文引用的文献

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Bilateral Pulmonary Embolism in Patients Recovered From Asymptomatic COVID-19 Infection.从无症状新冠病毒感染中康复的患者出现双侧肺栓塞
Cureus. 2021 Mar 12;13(3):e13848. doi: 10.7759/cureus.13848.
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Fatal pulmonary arterial thrombosis in a COVID-19 patient, with asymptomatic history, occurred after swab negativization.一名新型冠状病毒肺炎患者在咽拭子检测转阴后发生致命性肺动脉血栓形成,该患者既往无症状。
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Pulmonary Embolism and Deep Vein Thrombosis in COVID-19: A Systematic Review and Meta-Analysis.
新型冠状病毒肺炎相关肺栓塞及深静脉血栓形成的系统评价与荟萃分析。
Radiology. 2021 Feb;298(2):E70-E80. doi: 10.1148/radiol.2020203557. Epub 2020 Dec 15.
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A case-report of widespread pulmonary embolism in a middle-aged male seven weeks after asymptomatic suspected COVID 19 infection.一名中年男性在无症状疑似新冠病毒19感染七周后发生广泛肺栓塞的病例报告。
Thromb J. 2020 Aug 28;18:19. doi: 10.1186/s12959-020-00235-w. eCollection 2020.
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Insidious development of pulmonary embolism in asymptomatic patients with COVID-19: Two rare case-reports.新型冠状病毒肺炎(COVID-19)无症状患者中肺栓塞的隐匿性发展:两例罕见病例报告
Respir Med Case Rep. 2020;31:101186. doi: 10.1016/j.rmcr.2020.101186. Epub 2020 Aug 11.
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Venous thromboembolism and coronavirus disease 2019 in an ambulatory care setting - A report of 4 cases.门诊环境中的静脉血栓栓塞和 2019 年冠状病毒病 - 4 例报告。
Thromb Res. 2020 Oct;194:116-118. doi: 10.1016/j.thromres.2020.06.032. Epub 2020 Jun 19.
7
Development of pulmonary embolism in a nonhospitalized patient with COVID-19 who did not receive venous thromboembolism prophylaxis.COVID-19 非住院患者未接受静脉血栓栓塞预防而发生肺栓塞。
Am J Health Syst Pharm. 2020 Nov 16;77(23):1957-1960. doi: 10.1093/ajhp/zxaa286.
8
Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic.心血管考虑因素在 COVID-19 大流行期间的患者、医护人员和卫生系统。
J Am Coll Cardiol. 2020 May 12;75(18):2352-2371. doi: 10.1016/j.jacc.2020.03.031. Epub 2020 Mar 19.
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Prominent changes in blood coagulation of patients with SARS-CoV-2 infection.SARS-CoV-2 感染患者凝血功能的显著变化。
Clin Chem Lab Med. 2020 Jun 25;58(7):1116-1120. doi: 10.1515/cclm-2020-0188.