葡萄糖-6-磷酸脱氢酶缺乏症患者并发特发性史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症时，二甲双胍诱发的溶血。
Metformin-Induced Hemolysis in a Patient With Glucose-6-Phosphate Dehydrogenase Deficiency Presenting With Concurrent Idiopathic Steven-Johnson Syndrome/Toxic Epidermal Necrolysis.
作者信息
Roy Choudhury Avijoy, Gadaga Cecilia, Moodley Layuren, Moodley Aru
机构信息
Internal Medicine, The University of Western Australia (UWA) Medical School, Perth, AUS.
Internal Medicine, Texila American University, Texas, USA.
出版信息
Cureus. 2021 Oct 5;13(10):e18506. doi: 10.7759/cureus.18506. eCollection 2021 Oct.
Abstract
Metformin is one of the most widely prescribed medications for type 2 diabetes. While extremely rare, metformin has been reported to cause hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency. In this paper, we present a case of a patient with previously undiagnosed glucose-6-phosphate dehydrogenase deficiency who presented with hemolysis likely induced by metformin. The patient concurrently presented with idiopathic Steven-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Metformin causing hemolysis is extremely rare but considering the severe outcomes, it is something that medical practitioners need to be aware of.
摘要
二甲双胍是治疗2型糖尿病最常用的药物之一。虽然极为罕见，但有报道称二甲双胍可导致葡萄糖-6-磷酸脱氢酶缺乏症患者发生溶血。在本文中，我们报告了一例先前未被诊断出葡萄糖-6-磷酸脱氢酶缺乏症的患者，该患者出现了可能由二甲双胍诱发的溶血。该患者同时还患有特发性史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症（SJS/TEN）。二甲双胍导致溶血极为罕见，但鉴于其严重后果，这是医生需要注意的情况。
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