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鲍曼不动杆菌相关性尿路感染后急性横贯性脊髓炎的罕见病因,仅对静脉注射甲泼尼龙冲击疗法有效。

An Uncommon Cause of Acute Transverse Myelitis Following Acinetobacter Baumannii-Associated UTI, Which Responded to Intravenous Pulse Methylprednisolone Alone.

作者信息

Sharma Dibya J, Sarma Phulen, Saha Laky, Masroor Abunasar M

机构信息

Internal Medicine: Gastroenterology, Silchar Medical College and Hospital, Silchar, IND.

Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IND.

出版信息

Cureus. 2021 Oct 5;13(10):e18509. doi: 10.7759/cureus.18509. eCollection 2021 Oct.

DOI:10.7759/cureus.18509
PMID:34754669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8569673/
Abstract

Acute transverse myelitis (ATM) is a non-compressive localized inflammation involving one or more levels of the spinal cord due to various etiologies characterized by motor weakness, sensory impairments, and autonomic dysfunction. It can be idiopathic or primary or secondary due to infection, autoimmune disorder, connective tissue disorder, and uncommonly after vaccination which came to the limelight during the ongoing massive vaccine drive against coronavirus disease 2019 (COVID-19). We report a case of a 21-years-old male who presented with gradually progressive weakness of both lower limbs following urinary tract infection (UTI) with a history of similar illness in the family which improved with high dose methylprednisolone and antibiotic therapy followed by physical rehabilitation. A diagnosis of long segment ATM possibly following UTI was suggested after ruling out other secondary causes and was confirmed by magnetic resonance imaging (MRI) of the spinal cord. Asymmetric symptoms and signs with small lesions involving <two vertebral segments, peripheral lesion, presence of Lhermitte's sign and relapsing-remitting course distinguish ATM from more debilitating disorder multiple sclerosis (MS) in patients with family history. Infection like UTI can precipitate ATM as well as UTI may develop along with neurogenic lower urinary tract dysfunction (NLUTD) even after recovery from the motor and sensory impairment. Patients with acute transverse myelitis need to be on regular follow up particularly those with subacute presentation and positive family history to rule out relapse and development of multiple sclerosis. Common etiologies like UTI may precipitate uncommon disorders like ATM.

摘要

急性横贯性脊髓炎(ATM)是一种非压迫性局部炎症,由于各种病因累及脊髓的一个或多个节段,其特征为运动无力、感觉障碍和自主神经功能障碍。它可以是特发性的,或原发性或继发性的,病因包括感染、自身免疫性疾病、结缔组织疾病,在针对2019冠状病毒病(COVID-19)的大规模疫苗接种过程中,接种疫苗后引发该病的情况较为罕见。我们报告一例21岁男性病例,该患者在尿路感染(UTI)后出现双下肢逐渐进行性无力,其家族中有类似疾病史,经大剂量甲基泼尼松龙和抗生素治疗以及物理康复后病情改善。在排除其他继发原因后,怀疑可能是UTI后发生的长节段ATM,并经脊髓磁共振成像(MRI)证实。不对称的症状和体征、累及<两个椎体节段的小病变、周围病变、Lhermitte征的存在以及复发-缓解病程,可将有家族史患者的ATM与更严重的疾病多发性硬化症(MS)区分开来。像UTI这样的感染可引发ATM,并且即使在运动和感觉障碍恢复后,UTI也可能与神经源性下尿路功能障碍(NLUTD)一起出现。急性横贯性脊髓炎患者需要定期随访,尤其是那些亚急性表现且家族史阳性的患者,以排除复发和多发性硬化症的发生。像UTI这样的常见病因可能引发像ATM这样的罕见疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d541/8569673/4688ab067504/cureus-0013-00000018509-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d541/8569673/af02dc4e03ff/cureus-0013-00000018509-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d541/8569673/4688ab067504/cureus-0013-00000018509-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d541/8569673/af02dc4e03ff/cureus-0013-00000018509-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d541/8569673/4688ab067504/cureus-0013-00000018509-i02.jpg

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