头颈部癌吞咽困难优化调强放疗治疗计划的质量保证

Tyler Justine, Bernstein David, Seithel Matthew, Rooney Keith, Petkar Imran, Miles Elizabeth, Clark Catharine H, Hall Emma, Nutting Chris

National Radiotherapy Trials Quality Assurance Group, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK.

The Institute of Cancer Research, 123 Old Brompton Road, London SW7 3RP, UK.

Phys Imaging Radiat Oncol. 2021 Oct 26;20:46-50. doi: 10.1016/j.phro.2021.10.003. eCollection 2021 Oct.

This study aimed to assess the impact of the margin applied to the clinical target volume, to create the planning target volume, on plan quality of a novel dysphagia-optimised intensity modulated radiotherapy technique developed within a head and neck cancer multicentre randomised controlled trial. Protocol compliant plans were used for a single benchmark planning case. Larger margins were associated with higher doses to adjacent organs at risk, particularly the inferior pharyngeal constrictor muscle, but coincided with some improved low dose target coverage. A 3 mm margin is recommended for this technique if local practices allow.

本研究旨在评估在一项头颈癌多中心随机对照试验中开发的新型吞咽困难优化调强放疗技术中，应用于临床靶区以创建计划靶区的边界对计划质量的影响。符合方案的计划用于单个基准计划病例。较大的边界与相邻危及器官接受更高剂量相关，尤其是下咽缩肌，但同时也伴随着低剂量靶区覆盖的一些改善。如果当地条件允许，推荐该技术使用3毫米的边界。