Coward Stephanie, Windsor Joseph W, Kuenzig M Ellen, Bitton Alain, Bernstein Charles N, Jones Jennifer L, Khanna Reena, Lee Kate, Murthy Sanjay K, Targownik Laura, Benchimol Eric, Huang James Guoxian, Mukhtar Mariam S, Tandon Parul, Kaplan Gilaad G
Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
J Can Assoc Gastroenterol. 2021 Nov 5;4(Suppl 2):S20-S26. doi: 10.1093/jcag/gwab029. eCollection 2021 Dec.
At the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there were many unknowns: transmission vectors of the virus, appropriate intervention strategies and if being immunocompromised due to inflammatory bowel disease (IBD), for example, or medications put a person at increased risk for severe COVID-19. Imposing and relaxing of public health restrictions at different times and in different regions in Canada led to different epidemiologies of the virus in different provinces and territories. In order to understand the waxing and waning of waves of the COVID-19 pandemic, it is necessary to understand the effective reproductive number ( ) and the countervailing forces that exert upward or downward pressure on the spread of the virus at a given point in time. As many regions in Canada deal with a third wave, the primary forces affecting the of severe acute respiratory syndrome coronavirus 2 are variants of concern and the increasing vaccinations of Canadians leading to increased population-level immunity. Fortunately, for the IBD population, current research suggests that those with IBD are not at increased risk of contracting COVID-19, nor of having a more severe disease course when compared to the general population.
在2019冠状病毒病（COVID-19）大流行初期，存在许多未知因素：病毒的传播媒介、适当的干预策略，以及例如因炎症性肠病（IBD）导致免疫功能低下或药物治疗是否会使一个人患重症COVID-19的风险增加。加拿大不同时期、不同地区实施和放宽公共卫生限制措施，导致不同省份和地区出现不同的病毒流行情况。为了了解COVID-19大流行浪潮的起伏，有必要了解有效繁殖数（ ）以及在特定时间点对病毒传播施加向上或向下压力的抵消力量。随着加拿大许多地区应对第三波疫情，影响严重急性呼吸综合征冠状病毒2有效繁殖数的主要因素是值得关注的病毒变体以及加拿大人疫苗接种率的提高，从而使人群免疫力增强。幸运的是，对于IBD患者群体，目前的研究表明，与普通人群相比，IBD患者感染COVID-19的风险没有增加，病情也不会更严重。
