Atagi Kaya, Fukuhara Hideo, Ishiguro Motoyoshi, Osakabe Hiroto, Satoshi Fukata, Tamura Kenji, Karashima Takashi, Inoue Keiji
Department of Urology Kochi Medical School Kochi Japan.
IJU Case Rep. 2021 Aug 23;4(6):421-424. doi: 10.1002/iju5.12365. eCollection 2021 Nov.
Primary squamous cell carcinoma of the prostate is an extremely rare tumor with poor prognosis. Squamous cell carcinoma of the prostate is estimated to comprise less than 1% of all prostate carcinomas. We report herein a case with clinical response to docetaxel, cisplatin, and 5-fluorouracil chemotherapy with radiotherapy, in a patient with metastatic squamous cell carcinoma of the prostate.
A 74-year-old man consulted with frequent urination. The prostate-specific antigen level was 1.62 ng/mL. Multiparametric magnetic resonance imaging showed prostate imaging and reporting and data system category 5 for the whole prostate and biopsy was performed. The pathological diagnosis was pure squamous cell carcinoma of the prostate. fluorodeoxyglucose positron emission tomography showed fluorodeoxyglucose accumulation in the whole prostate and multiple pelvic lymph nodes. Four cycles of docetaxel, cisplatin, and 5-fluorouracil regimen were administrated along with radiotherapy. The patient showed a marked response with no major adverse events.
The present case suggests the potential of docetaxel, cisplatin, and 5-fluorouracil chemotherapy with radiotherapy for squamous cell carcinoma of the prostate.
前列腺原发性鳞状细胞癌是一种极其罕见的肿瘤，预后较差。据估计，前列腺鳞状细胞癌在所有前列腺癌中所占比例不到1%。我们在此报告一例转移性前列腺鳞状细胞癌患者，其对多西他赛、顺铂和5-氟尿嘧啶化疗联合放疗有临床反应。
一名74岁男性因尿频前来就诊。前列腺特异性抗原水平为1.62 ng/mL。多参数磁共振成像显示整个前列腺的前列腺影像报告和数据系统分类为5类，并进行了活检。病理诊断为前列腺纯鳞状细胞癌。氟脱氧葡萄糖正电子发射断层扫描显示整个前列腺和多个盆腔淋巴结有氟脱氧葡萄糖积聚。多西他赛、顺铂和5-氟尿嘧啶方案进行了4个周期的治疗，并联合放疗。患者显示出明显反应，无重大不良事件。
本病例提示多西他赛、顺铂和5-氟尿嘧啶化疗联合放疗对前列腺鳞状细胞癌具有潜在疗效。
