鼻息肉及其花生四烯酸代谢物含量
Nasal polyps and their content of arachidonic acid metabolites.
作者信息
Nigam S, Kunkel G, Herold D, Baumer F E, Jusuf L
出版信息
N Engl Reg Allergy Proc. 1986 Mar-Apr;7(2):109-12. doi: 10.2500/108854186779047753.
In three different groups of patients with nasal polyps without or with bronchial hyperreactivity and aspirin-sensitivity the content of several prostaglandin metabolites and LTC4 were measured in the polyp-tissue. A significant elevation of Thromboxane formation (TxB2) was found. The pathophysiological importance of this finding for the development of bronchial hyperreactivity in these patients is seen in context with the non-cholinergic stimulating system with consecutive substance P-formation and the role of the eosinophil cell in chronic inflammation.
在三组分别有无支气管高反应性和阿司匹林敏感性的鼻息肉患者中，测定了息肉组织中几种前列腺素代谢产物和白三烯C4的含量。发现血栓素生成（血栓素B2）显著升高。结合非胆碱能刺激系统及后续P物质的生成以及嗜酸性粒细胞在慢性炎症中的作用，可看出这一发现对这些患者支气管高反应性发展的病理生理重要性。
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