Squire E N, Nelson H S
N Engl Reg Allergy Proc. 1987 Mar-Apr;8(2):113-5. doi: 10.2500/108854187778994473.
Whether the administration of corticosteroids affects the disposition of theophylline remains unclear. Increased clearance, decreased clearance, and no change in clearance are all reported with steroid doses that are used in the treatment of asthma. This study found that theophylline kinetics among two normal subjects did not change after corticosteroids, while in one normal adult, clearance was significantly higher after corticosteroids. Additional study will be needed to ascertain if oral corticosteroids given over a short period may affect theophylline disposition in some patients.
皮质类固醇的使用是否会影响茶碱的处置尚不清楚。在治疗哮喘时使用的类固醇剂量下，清除率增加、清除率降低以及清除率无变化均有报道。本研究发现，两名正常受试者在使用皮质类固醇后茶碱动力学没有变化，而在一名正常成年人中，使用皮质类固醇后清除率显著更高。需要进一步研究以确定短期给予口服皮质类固醇是否可能影响某些患者的茶碱处置。
