Straughn A B, Henderson R P, Lieberman P L, Self T H
Ther Drug Monit. 1984;6(2):153-6. doi: 10.1097/00007691-198406000-00004.
The concentrations of theophylline from single 400-mg oral doses were evaluated both before and after 7 days of oral rifampin administration (600 mg/day) in six healthy, nonsmoking adults. The mean oral clearance of theophylline was significantly increased from 54.9 +/- 21.2 to 68.9 +/- 26.5 ml/h/kg. The elimination rate constant was significantly increased in five of the six subjects, with a mean increase of approximately 25%. Although intersubject variability was large, these data indicate the potential need to increase theophylline doses in some patients receiving rifampin.
在6名健康、不吸烟的成年人中，评估了口服利福平（600毫克/天）7天前后单次口服400毫克茶碱的血药浓度。茶碱的平均口服清除率从54.9±21.2显著增加至68.9±26.5毫升/小时/千克。6名受试者中有5名的消除速率常数显著增加，平均增加约25%。尽管个体间差异较大，但这些数据表明，一些接受利福平治疗的患者可能需要增加茶碱剂量。
