J Refract Surg. 2021 Nov;37(11):734-740. doi: 10.3928/1081597X-20210730-02. Epub 2021 Nov 1.
To investigate 2-year visual outcomes, stability, and predictability after allogenic lenticule implantation in a 100-µm pocket for moderate to high hyperopia correction.
In this prospective case series, 14 eyes of 9 patients with moderate to high hyperopia ranging from +3.00 to +8.00 diopters sphere were included between March and September 2018. Allogenic lenticules extracted from myopic small incision lenticule extraction were implanted into a pocket created by femtosecond laser at a 100-µm depth in recipients with hyperopia. All patients were followed up for 2 years. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity, manifest refraction, corneal topography, Fourier-domain optical coherence tomography, and in vivo confocal microscopy were examined.
At postoperative 2 years, 2 eyes (14.3%) gained one line of CDVA, 11 eyes (78.6%) had unchanged CDVA, and 1 eye (7.1%) lost one line of CDVA. No eyes lost two or more lines of CDVA. Twelve of the treated eyes (85.7%) had postoperative uncorrected near visual acuity equal to or better than pre-operative values. The spherical equivalent decreased from +5.53 ± 1.45 D preoperatively to -0.60 ± 1.20 D at postoperative year 2 ( < .001). The anterior mean keratometric readings increased from 42.41 ± 1.03 D preoperatively to 48.38 ± 1.98 D at postoperative year 2 ( < .001). Of 14 treated eyes, 10 eyes (71.4%) had spherical equivalent within ±1.00 D.
The findings suggest that allogenic lenticule transplantation may be a promising option for the correction of moderate to high hyperopia. .
研究同种异体透镜植入 100µm 口袋中矫正中高度远视的 2 年视觉效果、稳定性和可预测性。
在这项前瞻性病例系列研究中,纳入了 2018 年 3 月至 9 月间 9 名中高度远视患者(球镜度数为+3.00 至+8.00 屈光度)的 14 只眼。将从近视小切口透镜提取术(SMILE)中提取的同种异体透镜植入到远视受者的 100µm 深度的飞秒激光创建的口袋中。所有患者均随访 2 年。检查未矫正(UDVA)和矫正(CDVA)远视力、主观验光、角膜地形图、傅里叶域光学相干断层扫描(OCT)和共焦显微镜。
术后 2 年,2 只眼(14.3%)获得 1 行 CDVA,11 只眼(78.6%)CDVA 无变化,1 只眼(7.1%)下降 1 行。没有眼睛损失两行或更多行的 CDVA。12 只治疗眼(85.7%)术后的未矫正近视力等于或优于术前。球镜等效值从术前的+5.53±1.45D 降低至术后 2 年的-0.60±1.20D(<0.001)。术前平均角膜前表面读数为 42.41±1.03D,术后 2 年增加至 48.38±1.98D(<0.001)。14 只治疗眼中,10 只眼(71.4%)的球镜等效值在±1.00D 以内。
研究结果表明同种异体透镜移植可能是矫正中高度远视的一种有前途的选择。