Williams D, Wickramasinghe S N, Hulme B
Scand J Haematol. 1978 Mar;20(3):258-64. doi: 10.1111/j.1600-0609.1978.tb02455.x.
The changes in MCV at various times after renal transplantation were studied in a group of patients with functioning cadaveric renal grafts who had received azathioprine from the time of transplantation and in a constant dose from 2-8 weeks later. A post-transplantation increase in the MCV was seen in the majority of the cases studied and in these cases the MCV did not reach a maximum value until as long as 11-40 months after transplantation. In most cases the MCV then feel although frequently not to within the normal range and in some cases it showed further fluctuations. These data suggest gradual alterations over a period of years in the various cytokinetic changes which serve to maintain a reasonably high output of red cells from the marrow despite the cytotoxic effects of azathioprine.
对一组接受尸体肾移植且移植后即开始使用硫唑嘌呤并从2至8周后开始维持恒定剂量的患者，研究了肾移植后不同时间平均红细胞体积（MCV）的变化。在所研究的大多数病例中，移植后出现了MCV升高，并且在这些病例中，MCV直到移植后长达11至40个月才达到最大值。在大多数情况下，随后MCV下降，尽管常常未降至正常范围内，并且在某些情况下还出现了进一步波动。这些数据表明，尽管硫唑嘌呤具有细胞毒性作用，但在数年时间里各种细胞动力学变化会逐渐改变，以维持骨髓中红细胞的合理高输出量。
