Sjögren U, Thysell H, Lindholm T
Scand J Haematol. 1981 Mar;26(3):182-6. doi: 10.1111/j.1600-0609.1981.tb01645.x.
The bone marrow was morphologically analysed in 25 patients receiving long-term azathioprine therapy for chronic renal diseases or after a renal transplantation. There were no significant changes within the granulopoietic or lymphopoietic part of bone marrow even after 10 years of treatment. However, there was a significant "shift to the left" within erythropoiesis as well as greater frequencies of megaloblasts and sideroblasts. A significant increase of "erythroblastic islands" may indicate an increased death rate of defective erythroblasts. The changes within erythropoiesis in some of the patients were so pronounced that the possibility of a preleukaemic condition cannot be excluded.
对25例因慢性肾病接受长期硫唑嘌呤治疗或肾移植后的患者进行了骨髓形态学分析。即使经过10年治疗，骨髓的粒细胞生成或淋巴细胞生成部分也没有显著变化。然而，红细胞生成过程中出现了明显的“左移”，同时巨幼红细胞和铁粒幼红细胞的频率增加。“红细胞岛”的显著增加可能表明有缺陷的成红细胞死亡率增加。部分患者红细胞生成的变化非常明显，不能排除白血病前期状态的可能性。
