J Am Dent Assoc. 2022 Feb;153(2):175-182. doi: 10.1016/j.adaj.2021.07.015. Epub 2021 Oct 29.
Primary cutaneous cluster of differentiation 30-positive (CD30+) T-cell lymphoproliferative disorders are the second most common type of skin T-cell lymphoma. The lesions exhibit an indolent course, with a morphology resembling high-grade T-cell lymphoma.
A 67-year-old healthy man sought treatment for a large nonhealing ulcer on the buccal gingiva of the mandibular right premolars. He reported a history of recurrent cutaneous lesions, for which he was seen 1 year earlier at a hospital. Results of incisional biopsy showed a dense lymphoid cell infiltrate composed of atypical CD30+ T-cells intermixed with eosinophils. The diagnosis was updated to CD30+ T-cell lymphoproliferative disorder, which was similar to the cutaneous lesion diagnosis. The lesion area healed completely, and there were no signs of recurrence at 18-month follow-up.
Oral CD30+ T-cell lymphoproliferative disorder has a favorable outcome, but it is commonly misdiagnosed. Biopsy is crucial and should be combined with clinical examination to avoid chemotherapeutic treatments intended for high-grade lymphoma.
原发性皮肤 CD30+（分化群 30 阳性）T 细胞淋巴增生性疾病是第二类最常见的皮肤 T 细胞淋巴瘤。病变表现为惰性病程，形态类似于高级别 T 细胞淋巴瘤。
一名 67 岁健康男性因右下前磨牙颊侧牙龈处一处大的不愈合溃疡就诊。他报告说曾有复发性皮肤病变，一年前在一家医院就诊。切开活检结果显示，致密的淋巴样细胞浸润由典型的 CD30+ T 细胞与嗜酸性粒细胞混合组成。诊断更新为 CD30+ T 细胞淋巴增生性疾病，与皮肤病变的诊断相似。病变区域完全愈合，18 个月随访时无复发迹象。
口腔 CD30+ T 细胞淋巴增生性疾病预后良好，但常被误诊。活检至关重要，应结合临床检查，以避免针对高级别淋巴瘤的化疗治疗。
