Ficarra G, Prignano F, Romagnoli P
Institute of Stomatology, University of Florence, Italy.
Oral Oncol. 1997 Sep;33(5):375-9. doi: 10.1016/s1368-8375(97)00014-6.
Traumatic eosinophilic granuloma of the oral mucosa, also known as eosinophilic ulcer, is considered to be a reactive lesion of unknown aetiology. It usually presents as a tongue ulcer and injury has been considered to play a role in its cause. We present a 72-year-old man who had suffered multiple episodes of recurrent eosinophilic ulcers of the oral mucosa which underwent self-healing. Biopsy specimens (including fresh tissue) were studied with a combination of histology, electron microscopy and immunohistochemistry. A dense cell infiltrate composed of eosinophilis, lymphocytes and large mononuclear cells was constantly shown. Immunostains showed that the infiltrate was mainly composed of CD3+,CD4+,CD8-T-cells and CD1a + dendritic cells. Approximately 70% of the T-cells expressed CD30 (Ki-1) antigen. On the basis of the clinical behaviour, histology and antigenic features, it seems reasonable to suggest that traumatic eosinophilic granuloma of the oral mucosa may represent the oral countpart of primary cutaneous CD30 (Ki-1)-positive lymphoproliferative disorders. This group of cutaneous lymphomas are indeed characterised by non-aggressive clinical behaviour (sequential evolution in ulceration, necrosis and self-regression) and expression of CD30 antigen by the infiltrating large T-cells.
口腔黏膜创伤性嗜酸性肉芽肿，又称嗜酸性溃疡，被认为是一种病因不明的反应性病变。它通常表现为舌部溃疡，损伤被认为在其病因中起作用。我们报告一名72岁男性，他曾多次发生口腔黏膜复发性嗜酸性溃疡，均自行愈合。对活检标本（包括新鲜组织）进行了组织学、电子显微镜和免疫组织化学联合研究。持续显示出由嗜酸性粒细胞、淋巴细胞和大单核细胞组成的密集细胞浸润。免疫染色显示浸润主要由CD3 +、CD4 +、CD8 - T细胞和CD1a +树突状细胞组成。大约70%的T细胞表达CD30（Ki - 1）抗原。基于临床行为、组织学和抗原特征，提示口腔黏膜创伤性嗜酸性肉芽肿可能代表原发性皮肤CD30（Ki - 1）阳性淋巴增殖性疾病的口腔对应物似乎是合理的。这组皮肤淋巴瘤确实具有非侵袭性临床行为（溃疡、坏死和自我消退的顺序演变）以及浸润性大T细胞表达CD30抗原的特征。
