Sen Research Group, Biochemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100, Kütahya, Turkey.
Department of Chemistry, Faculty of Sciences, Dokuz Eylul University, Buca, İzmir, Turkey.
Chemosphere. 2022 Mar;291(Pt 3):132718. doi: 10.1016/j.chemosphere.2021.132718. Epub 2021 Oct 28.
In this study, a glucose sensor modified with activated carbon supported gold-nickel (AuNi@AC) metal nanoparticles was prepared for the early diagnosis of diabetes. Electrochemical tests were carried out by determining the optimum working conditions of the prepared glucose sensor. The characterization analyses of the designed glucose sensor were performed by Transmission Electron Microscopy (TEM), X-Ray Diffraction (XRD), X-Ray Photoelectron Spectroscopy (XPS) and Raman Spectroscopy. It was determined that the average particle size of the nanoparticles in the AuNi alloy structure was 2.03 ± 0.37 nm. The determined detection limit of the AuNi@AC nanosensor was calculated as 0.41 μM as a result of the high linear range provided up to 1.7 mM. In addition, the sensitivity of AuNi@AC nanosensor to glucose, which has a high sensitivity value of 1955 μA mM cm, was determined.
在这项研究中，制备了一种用活性炭负载的金镍（AuNi@AC）金属纳米粒子修饰的葡萄糖传感器，用于糖尿病的早期诊断。通过确定制备的葡萄糖传感器的最佳工作条件来进行电化学测试。通过透射电子显微镜（TEM）、X 射线衍射（XRD）、X 射线光电子能谱（XPS）和拉曼光谱对设计的葡萄糖传感器进行了表征分析。结果表明，AuNi 合金结构中纳米粒子的平均粒径为 2.03±0.37nm。AuNi@AC 纳米传感器的检测限确定为 0.41μM，这是由于高达 1.7mM 的高线性范围提供了高线性范围。此外，还确定了 AuNi@AC 纳米传感器对葡萄糖的灵敏度，其灵敏度值高达 1955μA·mM·cm。
