阿扑吗啡可改善精神分裂症症状。
Schizophrenic symptoms improve with apomorphine.
作者信息
Tamminga C A, Schaffer M H, Smith R C, Davis J M
出版信息
Science. 1978 May 5;200(4341):567-8. doi: 10.1126/science.347574.
PMID:347574
Abstract
Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.
摘要
18名慢性精神分裂症患者在不同试验中分别接受皮下注射多巴胺受体激动剂阿扑吗啡和安慰剂。与安慰剂相比，注射阿扑吗啡后精神病症状有显著改善。这些结果被解释为阿扑吗啡激活突触前多巴胺受体，随后多巴胺介导的神经传递减少的结果。
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