Corsini G U, Onali P, Masala C, Cianchetti C, Mangoni A, Gessa G
Arch Neurol. 1978 Jan;35(1):27-30. doi: 10.1001/archneur.1978.00500250031006.
Four patients affected by Huntington's chorea (HC) with a well defined family history of the disease were injected intramuscularly with apomorphine hydrochloride in nonemetic doses, ranging from 1 to 4 mg. Soon after treatment, all patients showed a marked decrease in abnormal involuntary movements. Pretreatment with haloperidol (2 mg intramuscularly) or sulpiride (100 mg intramuscularly) 30 minutes prior to apomorphine treatment, prevented the therapeutic effect of this compound. It is suggested that apomorphine-induced improvement in Huntington's Chorea is mediated by the stimulation of a special kind of dopamine receptor, leading to inhibition of the activity of dopaminergic neurons.
对4例有明确亨廷顿舞蹈症（HC）家族病史的患者肌肉注射非催吐剂量（1至4毫克）的盐酸阿扑吗啡。治疗后不久，所有患者的异常不自主运动均显著减少。在阿扑吗啡治疗前30分钟，先肌肉注射氟哌啶醇（2毫克）或舒必利（100毫克）进行预处理，可阻断该化合物的治疗效果。提示阿扑吗啡改善亨廷顿舞蹈症是通过刺激一种特殊的多巴胺受体介导的，从而抑制多巴胺能神经元的活性。
