Tarnawski A, Hollander D, Stachura J, Mach T, Bogdal J
Scand J Gastroenterol Suppl. 1987;127:111-23. doi: 10.3109/00365528709090961.
Twelve healthy volunteers were given a single sucralfate tablet (1 gm) orally. For 60 min after ingestion they were examined endoscopically for the localization and disintegration of the tablet in the stomach, and biopsies were taken to determine the effect of sucralfate on the histology and ultrastructure of the normal gastric mucosa. After ingestion, the sucralfate tablet had disintegrated and firmly adhered to a relatively small mucosal area of the greater curvature covering 5 +/- 2 and 7 +/- 2 cm2 at 15 and 30 minutes, and 9 +/- 3 cm2 at 60 minutes after drug ingestion. Histologic and ultrastructural examination of the mucosa in direct contact with sucralfate revealed distinct changes in the surface epithelial cells: mucus release, vacuolization, and exfoliation of some of the cells. Endoscopy offers a unique opportunity for the study of gastroduodenal effects and disposition of orally administered drugs.
12名健康志愿者口服一片硫糖铝片（1克）。服药后60分钟内，通过内镜检查观察药片在胃内的定位和崩解情况，并取活检组织以确定硫糖铝对正常胃黏膜组织学和超微结构的影响。服药后，硫糖铝片发生崩解，并牢固附着于胃大弯相对较小的黏膜区域，服药后15分钟和30分钟时覆盖面积分别为5±2平方厘米和7±2平方厘米，服药后60分钟时为9±3平方厘米。对与硫糖铝直接接触的黏膜进行组织学和超微结构检查发现，表面上皮细胞有明显变化：一些细胞出现黏液分泌、空泡化和脱落。内镜检查为研究口服药物对胃十二指肠的影响及处置情况提供了独特的机会。
