Tarnawski A, Hollander D, Krause W J, Zipser R D, Stachura J, Gergely H
Gastroenterology. 1986 Apr;90(4):893-905. doi: 10.1016/0016-5085(86)90865-6.
Although the action of sucralfate on ulcerated mucosa has been demonstrated, its effect on the histology, ultrastructure, and function of normal gastric mucosa is unknown. We investigated the effect of acute administration of sucralfate on the gastric mucosal history, ultrastructure, mucosal potential difference, and luminal release of prostaglandin E2. At 15 min, 1 h, and 3 h after intragastric instillation of sucralfate, whitish incrustations of the drug were firmly adhering to the glandular mucosa. Mucosal histology after sucralfate administration demonstrated the following: disruption and exfoliation of some of the surface epithelial cells, mucosal hyperemia, prominent release of mucus from the surface epithelial cells, and edema of lamina propria and submucosa. These changes were most prominent in the areas where sucralfate was in contact with the mucosal surface. Scanning and transmission electron microscopy confirmed the above changes. Sucralfate produced a drop in gastric mucosal potential difference and a significant increase in luminal release of prostaglandin E2. Sucralfate produces distinct morphologic and functional changes in the normal gastric mucosa, which may account for its preventive and therapeutic efficacy.
尽管已证实硫糖铝对溃疡黏膜有作用，但其对正常胃黏膜的组织学、超微结构及功能的影响尚不清楚。我们研究了急性给予硫糖铝对胃黏膜组织学、超微结构、黏膜电位差及前列腺素E2腔内释放的影响。在胃内滴注硫糖铝后15分钟、1小时和3小时，药物的白色结痂牢固地附着于腺性黏膜。给予硫糖铝后的黏膜组织学表现如下：部分表面上皮细胞破坏和脱落、黏膜充血、表面上皮细胞黏液显著释放以及固有层和黏膜下层水肿。这些变化在硫糖铝与黏膜表面接触的区域最为明显。扫描电镜和透射电镜证实了上述变化。硫糖铝使胃黏膜电位差降低，前列腺素E2腔内释放显著增加。硫糖铝可使正常胃黏膜产生明显的形态学和功能变化，这可能解释了其预防和治疗效果。
